关键词: 蛋白质, 蛋白质相互作用, CyClus3D聚类算法, 网络模体, 富集分析

Abstract:

To study the interactions between proteins, the 3D spectral clustering algorithm in Cytoscape（CyClus3D）is applied to
identify the network motifs of integrated protein-protein interaction（PPI）networks, including Human Protein Reference Database
（HPRD）, Human Interactome Resource（HIR）, and Biological General Repository for Interaction Datasets（BioGRID）databases.
Then, enrichment analysis of GO（Gene Ontology）biological process and KEGG（Kyoto Encyclopedia of Genes and Genomes）
pathways in the sub-networks formed by network motifs is conducted. The results show that network motif could simplifythe analysis of
PPI networks, and could focus on analyzing key proteins.

Key words: protein, protein-protein interaction, 3D spectral clustering algorithm, network motif, enrichment analysis