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大理大学学报
月刊，1980年创刊

主管：云南省教育厅
主办：大理大学
地址：云南省大理市古城弘圣路2号
　　　大理大学学报编辑部
邮编：671003
电话：0872-2219939，
　　　0872-2219133 (社会科学类)
　　　0872-2219938 (医学类)
　　　0872-2218160 (理工类)
Email: dldxxuebao@163.com
ISSN: 2096-2266
CN: 53-1232/Z

15 October 2025, Volume 10 Issue 10

Previous Issue

Study on the Antiplatelet Activities of Astragalus bhotanensis and A. yunnanensis subsp. incanus

Zhuo Jiayan, , Duan Yangyang, Sun He, Jiang Bei, Shen Lei,

2025, 10(10): 1-6. DOI: ［DOI］ 10. 3969 / j. issn. 2096-2266. 2025. 10. 001

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〔Abstract〕 Objective: To explore the antiplatelet activities of Astragalus bhotanensis and A. yunnanensis subsp. incanus, and compare
them with A. membranaceus, to evaluate their potential application value in the prevention and treatment of cardiovascular diseases.
Methods: The effects of ethanol extracts from A. membranaceus and six species of Astragalus plants in Yunnan on ADP-induced
platelet aggregation, collagen-induced ATP release and platelet adhesion were compared in vitro. The evaluation was performed by
optical turbidimetry, ATP content measurement, and phalloidin fluorescent staining. Results: The A. membranaceus, A. bhotanensis, A.
yunnanensis subsp. incanus and A. tongolensis significantly inhibited ADP-induced platelet aggregation at a certain concentration （P<
0.05）. Among them, A. bhotanensis and A. yunnanensis subsp. incanus can significantly reduce the ATP release induced by collagen
and inhibit the adhesion of platelets on the surface of collagen, and their action intensity was similar to that of A. membranaceus, while
the other Astragalus plants in Yunnan had no obvious activity. Conclusion: A. bhotanensis and A. yunnanensis subsp. incanus have
similar activities to A. membranaceus in anti-platelet aggregation, release and adhesion, suggesting that they are potential candidates
for antithrombotic drugs, but their active components and mechanisms need further study.

Exploration of the Postgraduate Training Model in Biology and Pharmacy Based on Medicine-Engineering Integration#br#

Ouyang Yifan, , Wang Jiwei, , Wei Dingtai, Shen Chengwan,

2025, 10(10): 7-11. DOI: ［DOI］ 10. 3969 / j. issn. 2096-2266. 2025. 10. 002

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〔Abstract〕 This study explores the postgraduate training model of biology and pharmacy based on medicine-engineering integration.
By analyzing the current state of training models and the importance of medicine-engineering integration, this paper elaborates on the
development process, current status, and challenges of the integrated training model for biology and pharmacy majors. It proposes
innovative approaches, including restructuring the curriculum system, building supervisor teams, and enhancing practical teaching.
The results are demonstrated through a training pilot project at Ningde Normal University. Finally, the research conclusions are
summarized, and future development directions are outlined, including continuous optimization of curriculum system, in-depth
expansion of practical teaching, and strengthened development of supervisor team.

Research Progress on the Chemical Constituents and Pharmacological Activities of the She Ethnomedicine Vaccinium bracteatum

Wang Miao, , , Liu Jianling, , Zhou Pengqian, , Zheng Miaoru, , Li Yi, , Shen Chengwan,

2025, 10(10): 12-21. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 003

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〔Abstract〕Vaccinium bracteatum Thunb., a member of the genus Vaccinium in the family Ericaceae, is a She ethnomedicine with a

long history of being used for both medicinal and edible purposes. It also serves as the primary raw material for the traditional She

ethnic food "Wumifan" （Black Rice）. The leaves, fruits, and roots of V. bracteatum have been used medicinally, with its therapeutic

properties recorded in numerous classical materia medica texts. Modern studies have shown that V. bracteatum is rich in flavonoids,

terpenoids, phenylpropanoids, polysaccharides, and other chemical constituents, and possesses diverse pharmacological activities such

as antibacterial, antifatigue, antioxidant, vision-protective, neuroprotective, antidepressant, hypoglycemic, and antitumor effects. This

review summarizes research progress on the chemical constituents and pharmacological activities of V. bracteatum over the past four

decades, providing a reference for its further development and utilization.

Effects of PSCA Expression on Migration, Proliferation, and Invasion of Pancreatic Cancer Cells

Wang Xianyu , Mao Jianhua , Wu Bihua , Su Shuangyan , He Jinlong , Liang Qilang , Chen Yiming,

2025, 10(10): 22-31. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 004

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〔Abstract〕 Objective: To investigate the expression of prostate stem cell antigen （PSCA） in pancreatic cancer cells and its effects on

cell migration, proliferation, and invasion. Methods: Stable Panc1 cell lines with PSCA overexpression and knockdown were

established using lentiviral vectors. PSCA expression levels were detected by qPCR and Western blotting. Functional assays, including

wound healing, CCK-8 proliferation, and Transwell invasion assays, were performed to assess cellular behavior. Results:

Immunohistochemistry demonstrated that PSCA was primarily localized on the cell membrane. PSCA overexpression significantly

increased mRNA levels （P<0.001）, whereas protein expression showed no statistically significant change （P>0.05）. Functional assays

revealed that PSCA overexpression markedly enhanced Panc1 cell migration （48 and 72 h, P<0.05）, proliferation （72 h, P<0.05）, and

invasion （48 h, P<0.05）. Conclusion: PSCA overexpression can promote proliferation, migration, and invasion of pancreatic cancer

cells through mRNA-level effects or potential indirect mechanisms. These findings suggest a pro-tumorigenic role of PSCA in

pancreatic cancer progression and provide an experimental basis for further investigation of its molecular mechanisms.

Expression and Prognostic Significance of TRIM28 in Pleural Mesothelioma

He Jintao, , Li Hanwei , Wang Xiaoyi, , Yang Yongqin , Zhang Yepin , Mei Wen , Xiong Wei,

2025, 10(10): 30-38. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 005

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〔Abstract〕 Objective: To investigate the expression characteristics and prognostic value of the tripartite motif-containing 28

（TRIM28） in pleural mesothelioma （PM）. Methods: Combining TCGA, GEO databases, and clinical samples, the expression level,

prognostic relationship, and association with immune infiltration of TRIM28 were analyzed. The expression differences were verified by

real-time fluorescence quantitative PCR and immunohistochemical staining, and a protein interaction network was constructed using

the String database. Results: TRIM28 was significantly overexpressed in PM tissues and cells, and its expression level was significantly

correlated with tumor stage, patient age, and tumor type （P<0.05）. Both tumor type and TRIM28 expression level were significantly

correlated with patient prognosis （P<0.05）. Furthermore, TRIM28 gene overexpression was positively correlated with regulatory T cell

immune infiltration （P<0.05）. The ROC curve showed a good diagnostic performance for TRIM28. Gene enrichment analysis suggested

that it may be involved in PM progression through signaling pathways such as the cell cycle. Conclusion: TRIM28 may be an

independent prognostic factor and potential therapeutic target for PM.

Clinical Efficacy of Zhangwa Yiyang Ointment in Postpartum Disorders

Wang Jiaxin , Zhou Yiyuan

2025, 10(10): 39-42. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 006

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〔Abstract〕 Objective: To evaluate the clinical efficacy and safety of Zhangwa Yiyang Ointment in improving postpartum anemia,

inflammatory responses, uterine involution, and lactation. Methods: A total of 213 postpartum women treated at the First Affiliated

Hospital of Guizhou University of Traditional Chinese Medicine between December 2022 and December 2023 were enrolled.

Participants were randomly divided into the control group （n=122, treated with oxytocin only） and the observation group （n=91,

treated with Zhangwa Yiyang Ointment in addition to oxytocin）. Hemoglobin levels, D-dimer, inflammatory markers, uterine recovery

parameters, lactation outcomes, and adverse reactions were compared between the two groups before and after treatment. Results: After

treatment, hemoglobin levels increased while D-dimer, C-reactive protein, and white blood cell counts decreased in both groups, with

more significant improvement in the observation group （P<0.05）. The observation group also showed greater reductions in endometrial

thickness, intrauterine blood clot residual area, and uterine volume compared with the control group （P<0.01）. Furthermore, the time

to initial lactation was shorter, and the adequate lactation rate reached 89.01%, significantly higher than that of the control group （P<

0.01）. The incidence of adverse reactions was also lower in the observation group （P<0.05）. Conclusion: Zhangwa Yiyang Ointment

effectively improves hematological and inflammatory indicators, promotes uterine involution, enhances lactation, and demonstrates good

safety. It provides new clinical evidence for traditional Chinese medicine interventions in postpartum disorders.

Comparison of Ciprofol and Etomidate in Anesthesia for Painless Gastroscopy

Huang Biao, Dai Maolin, Xu Ling

2025, 10(10): 43-47. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 007

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〔Abstract〕 Objective: To compare the anesthetic efficacy and safety of ciprofol and etomidate in painless gastroscopy, providing a

reference for clinical drug selection. Methods: A total of 176 outpatients undergoing painless gastroscopy were randomly assigned to

the ciprofol group and the etomidate group, and received intravenous ciprofol （0.4 mg/kg） or etomidate （0.3 mg/kg）. Blood pressure,

heart rate, respiratory rate, and percutaneous arterial oxygen saturation （SpO

） were monitored. Recovery time, procedure duration,

adverse reactions, and satisfaction scores from both endoscopists and patients were recorded. Results: No significant differences were

observed between groups in gender, age, body mass index, or ASA classification. At endoscope insertion, blood pressure, mean arterial

pressure, and SpO

were significantly lower in the ciprofol group compared with the etomidate group （P<0.05）, whereas overall

incidences of hypotension and hypoxemia showed no statistical difference. The ciprofol group demonstrated shorter recovery time （P=

0.006） and higher endoscopist satisfaction （P=0.001）. Patient satisfaction and complication rates were comparable between groups.

Conclusion: Both ciprofol and etomidate are effective and safe for painless gastroscopy. Ciprofol offers faster recovery and higher

operator satisfaction, indicating promising clinical application potential.

Value of D-Dimer, FDP Combined with Caprini Score in Predicting Deep Vein Thrombosis in Patients with Lower Extremity Soft Tissue Trauma

Gao Yongli , Dong Haogang , Liu Jianping , Zhang Kaiquan , Ma Binbin

2025, 10(10): 48-53. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 008

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〔Abstract〕 Objective: To explore the clinical value of D-dimer, fibrin degradation product （FDP） combined with Caprini score in

predicting the formation of deep vein thrombosis （DVT） in patients with lower extremity soft tissue trauma. Methods: A retrospective

cohort study was conducted. A total of 363 patients with lower extremity soft tissue trauma admitted to the orthopedics department and

emergency trauma center of People's Hospital of Yuxi City in Yunnan Province from January 2020 to December 2021 were selected as

the research subjects. Among them, 32 patients diagnosed with DVT were included in the DVT group, and 331 patients undiagnosed

were included in the non-DVT group. The levels of D-dimer and FDP in the two groups of patients were detected, the Caprini score

was evaluated, the relationship between the three and DVT was analyzed, and the ROC curve was drawn to evaluate the predictive

efficacy. Results: The levels of D-dimer, FDP and Caprini score in the DVT group were significantly higher than those in the non

DVT group （P<0.001）. D-dimer, FDP and Caprini score were positively correlated with DVT （r=0.305, P<0.01; r=0.222, P<0.01;

r=0.517, P<0.01）. The AUC of the joint prediction model was 0.944, with a sensitivity of 100.0% and a specificity of 79.8%,

outperforming each individual indicator. Conclusion: D-dimer, FDP combined with Caprini score can effectively predict the

occurrence risk of DVT after lower extremity soft tissue trauma and has high clinical application value.

Study on the Correlation between Vitamin D Receptor Gene Polymorphism and Urinary Calculi in the Bai Ethnic Group in Dali, Yunnan

Liu Chenyinan , Xiao Zhisong , Wang Guangming , Zheng Baoshou , Duan Fuhui , Li Yunpeng

2025, 10(10): 54-59. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 009

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〔Abstract〕 Objective: To explore the relationship between the polymorphisms of vitamin D receptor （VDR） genes ApaI （rs7975232）,

BsmI （rs1544410）, TaqI （rs731236）, and FokI （rs2228570） and urolithiasis in the Bai ethnic group in Dali, Yunnan. Methods: Four

polymorphic loci of the VDR gene in 92 Bai patients with urinary calculi and 54 healthy Bai subjects undergoing physical examinations

were detected by ligase detection reaction technology, and the polymorphic distribution was investigated. Results: All polymorphic loci

observed in this study conformed to the law of genetic equilibrium. The polymorphisms of the TaqI and FokI loci in the VDR gene were

associated with the susceptibility of urinary calculi in the Bai ethnic group in Dali, Yunnan. Conclusion: The t allele （Tt/tt genotype） at

the TaqI locus of the VDR gene may be a genetic risk factor for urinary calculi in the Bai ethnic group in Dali, Yunnan. The f allele at the

FokI locus may be a protective factor （or related to dominant inheritance）. There is no significant association between the ApaI and

BsmI loci.

Analysis of Stone Composition of Urinary Calculi in 368 Patients from the Southern Yunnan Region

Zhong Cheng, Zhao Jinquan, Yang Zhiming, Yuan Ling

2025, 10(10): 60-65. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 010

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〔Abstract〕 Objective: To explore the composition characteristics and differences of urinary calculi in the southern Yunnan region.

Methods: A retrospective analysis was conducted on the clinical data of 368 patients with urinary calculi who underwent surgical

treatment in Southern Central Hospital of Yunnan Province from January 2021 to January 2023. After the operation, the stone samples

were analyzed by infrared spectroscopy. The age, gender, location and composition of the stone of the patients were compared. The

epidemiological characteristics were analyzed and individualized preventive measures were provided.Results: Among the 368 patients

with calculi, the majority were middle-aged and elderly people. The detection rate was relatively high in the age group of 40-69 years

old. The prevalence rate in males was significantly higher than that in females （P<0.05）. Most of the stone samples were mixed

compositions. Calcium oxalate stones were the most common, while infectious stones, uric acid stones and other types of stones were

relatively rare. Uric acid stones were more common in male patients （P<0.05）, while calcium oxalate stones and infectious stones were

more likely to occur in female patients （P<0.05）. Upper urinary tract stones were more common than lower urinary tract stones, while

the incidence rate was higher in males than in females （P<0.05）, and there were gender differences in the composition and location of

calculi. Conclusion: The analysis of stone composition has significant clinical value for understanding the epidemiology of urinary

calculi in the southern Yunnan region and formulating individualized prevention and treatment measures.

Analysis of Drug Resistance and Influencing Factors in 243 AIDS Patients Treated with Antiretroviral Therapy

Zhang Shichen, , Yu Tingting , Li Chongxi , Yu Wenjun, , Han Dongliang , Pu Dong

2025, 10(10): 66-71. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 011

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〔Abstract〕 Objective: To explore the influencing factors of drug resistance in AIDS patients. Methods: The general clinical data of

243 AIDS patients receiving antiretroviral therapy at the Sixth Affiliated Hospital of Dali University from December 2019 to December

2020 were collected. Based on drug resistance status, the patients were divided into the drug resistance group （39 cases） and the non

drug resistance group （204 cases）. The χ2 test and Logistic regression were used to analyze the influencing factors of drug resistance in

AIDS patients. Results: The results of univariate analysis showed that there were statistically significant differences in the occurrence

of drug resistance between the two groups of patients in terms of marital status, education level, the selection of third-class drugs in the

initial treatment regimen, baseline CD4

T cell level before treatment, and WHO disease stage （P<0.05）. The results of multivariate

analysis showed that education level of junior college and above （OR=0.228, 95%CI=0.059-0.879） was a protective factor for drug

resistance in AIDS patients, and WHO disease stage Ⅱ, Ⅲ, Ⅳ（OR=2.388, 95%CI=1.030-5.538; OR=3.556, 95%CI=1.184-10.681;

OR=3.725, 95%CI=1.074-12.912） were the risk factors for drug resistance in AIDS patients. Conclusion: Marital status, education

level, initial treatment regimen, baseline CD4

T cell level before treatment and WHO disease stage were the influencing factors for drug

resistance after antiviral treatment for AIDS. These factors should be considered in the management of patients receiving antiretroviral

therapy.

Epidemiological Characteristics and Risk Factors of Non-Alcoholic Fatty Liver Disease in Obese Population

Li Yue, Zhang Qigang, Xu Liping, Pan Feng, Guo Xiaohua

2025, 10(10): 72-75. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 012

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〔Abstract〕 Objective: To analyze the epidemiological characteristics and related risk factors of non-alcoholic fatty liver disease

（NAFLD） in the obese population. Methods: A total of 1 500 obese patients who underwent physical examinations at the health

management center of Mianyang 404 Hospital in 2024 were selected as the research subjects. According to the results of liver

ultrasound examination, they were divided into the NAFLD group （600 cases） and the non-NAFLD group （900 cases）. Univariate

analysis and multivariate Logistic regression analysis were used to screen the independent risk factors of NAFLD in the obese

population. Results: Among 1 500 obese patients, the prevalence of NAFLD was 40.0%, with mild, moderate, and severe cases

accounting for 23.3%, 12.0%, and 4.7%, respectively. Multivariate Logistic regression analysis showed that age （OR=1.265, 95%CI:

1.068-1.495）, systolic blood pressure （OR=1.169, 95%CI: 1.034-1.321）, and fasting blood glucose （OR=1.383, 95%CI: 1.115-

1.714） and triglyceride （OR=1.578, 95%CI: 1.234-2.011） were independent risk factors of NAFLD in the obese population （P<0.05）.

Conclusion: The risk of NAFLD is significantly increased in obese population. Aging, elevated systolic blood pressure and glycolipid

metabolic disorder are the core pathogenic factors. An early intervention system incorporating the monitoring of these metabolic

parameters should be established in clinical practice.

Analysis of the Current Status and Influencing Factors of Depression among Middle-Aged and Elderly Stroke Patients Based on CHARLS

Wu Yueting, Zi Wenyan, Yang Yan, Li Wenwu, Xi Li

2025, 10(10): 76-83. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 013

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〔Abstract〕 Objective: To investigate the current status of depression among middle-aged and elderly stroke patients in China and

analyze the influencing factors. Methods: The samples of this study were derived from the 2018 survey data of the China Health and

Retirement Longitudinal Study （CHARLS）. Middle-aged and elderly patients aged 45 years or older and diagnosed with stroke were

selected as the research subjects （n=974）. The depressive symptoms of the research subjects were determined by the score of the

simplified Center for Epidemiological Studies Depression Scale （scores≥10 were defined as depression）, and binary Logistic regression

was used to analyze the influencing factors. Results: Among 974 middle-aged and elderly stroke patients, 599（accounting for

61.50%） had depressive symptoms. The results of binary Logistic regression analysis showed that age, gender, marital status,

hypertension, heart disease, self-rated health status, life satisfaction, self-care ability, physical disability, and language disorder were

influencing factors of depression in middle-aged and elderly stroke patients（P<0.05）. Conclusion: Based on the survey and analysis

of CHARLS 2018 data, the prevalence of depression among middle-aged and elderly stroke patients in China is relatively high and is

influenced by multiple factors.

Visualization Analysis of the Research Status and Hotspots in Cognitive Disorder among Older People Living with HIV Based on CiteSpace

Xue Qiaoting, Yan Wenjing, Yao Runlan, He Qilian

2025, 10(10): 84-93. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 014

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〔Abstract〕 Objective: To analyze the relevant literatures on cognitive disorder in older people living with HIV （OPLWH） through

bibliometric analysis, systematically presenting the knowledge network, evolutionary trends and collaborative structure in this field,

and to provide data support and reference for the development of cognitive interventions and policies for OPLWH in China. Methods:

The relevant literatures on cognitive disorder of OPLWH in the Web of Science Core Collection Database from January 1, 2009 to May

1, 2025 were retrieved. The results were visualized using CiteSpace software, and in-depth analyses were conducted from the

perspectives of keywords, authors, publishing countries, and keyword clustering. Results: A total of 2 085 articles were included, and

the number of literatures on cognitive disorder in OPLWH showed a trend of "low starting point, fast growth, and growth rate

slowdown". The United States ranked as the core research country with 1 015 publications and a centrality of 0.36. Vance David E was

the most prolific author. High frequency keywords included "dementia", "Alzheimer's disease", "prevalence",“risk”, "quality of life".

The analysis of the emergent words showed that the "dementia prevention", "intervention", "inflammation", "meta analysis",

"prevention" and "machine learning" had persisted to this day and were emerging research frontier directions. Conclusion: Current

research on cognitive disorder in OPLWH focuses on neurodegenerative mechanisms, risk factors and intervention strategies, but there

are problems such as unbalanced international collaboration and insufficient representativeness of data. In the future, it is necessary to

enhance multi-center collaboration and integrate interdisciplinary research methods to provide a scientific basis for optimizing

cognitive health management.

Exploration of Differentiated Teaching in Medical Genetics Courses

Zhao Qiong, Huang Hua

2025, 10(10): 94-100. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2025. 10. 015

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〔Abstract〕 Objective: To investigate the pedagogical models for cultivating interdisciplinary medical professionals with integrated

expertise and cross-disciplinary competencies. Methods: Students majoring in clinical medicine of the 2022 grade and nursing of the

2023 grade in the medical department of Jingchu University of Technology were selected as the research subjects. Class 1 of clinical

medicine of the 2022 grade and class 1 of nursing of the 2023 grade were set as the experimental group （implementing "Medical

Genetics + X" differentiated teaching）. Class 2 of clinical medicine of the 2022 grade and class 2 of nursing of the 2023 grade were set

as the control group （using traditional teaching）, and the assessment scores, clinical ability scores and teaching satisfaction of each

group were compared. Results: The assessment scores, clinical ability scores and teaching satisfaction of the experimental groups in

each major were all higher than those of the control group, and the differences were statistically significant （P<0.05）. Conclusion: The

"Medical Genetics + X" pedagogical innovation, which formulates differentiated teaching positioning and strategies, has achieved

certain results, providing a referenceable path for cultivating medical talents with interdisciplinary practical abilities in precision

medicine and full-cycle health management.