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大理大学学报
月刊，1980年创刊

主管：云南省教育厅
主办：大理大学
地址：云南省大理市古城弘圣路2号
　　　大理大学学报编辑部
邮编：671003
电话：0872-2219939，
　　　0872-2219133 (社会科学类)
　　　0872-2219938 (医学类)
　　　0872-2218160 (理工类)
Email: dldxxuebao@163.com
ISSN: 2096-2266
CN: 53-1232/Z

15 October 2024, Volume 9 Issue 10

Previous Issue

Chemical Constituents and Hypoglycemic Activity of Swertia punicea

Kang Shaolong , Wang Huiling , Li Dongmei , Xiao Huai

2024, 9(10): 1-5. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 001

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〔Abstract〕 Objective: To investigate the chemical constituents of Swertia punicea and screen the hypoglycemic activity of 1, 5, 8-

trihydroxy-3-methoxyxanthone and swertiamarin. Methods: The chemical constituents of S. punicea were isolated and purified using

column chromatography techniques, including silica gel, ODS, and MCI. The chemical constituents were identified and characterized

through thin-layer chromatography and spectroscopic data. The hypoglycemic activity was evaluated using alloxan-induced type 1

diabetic mice, with metformin serving as a positive control. The effects of the compounds on changes of body mass, food intake, water

consumption, and blood glucose levels were assessed. Results: Seven compounds were isolated from the n-butanol fraction of S.

punicea, identified as 1, 5, 8-trihydroxy-3-methoxyxanthone （1）, 1, 7-dihydroxy-3, 4, 8-trimethoxyxanthone （2）, swertiamarin （3）,

7-О-β-D-glucopyranosyl-1, 8-dihydroxy-3-methoxyxanthone （4）, amarogentin （5）, 7-O-［α-L-rhamnopyranosyl-（1→2）-β-D

xylopyranosyl］-1, 8-dihydroxy-3-methoxyxanthone （6）, mangiferin （7）. The results of hypoglycemic activity showed that 1, 5, 8-

trihydroxy-3-methoxyxanthone significantly reduced food intake, water consumption, and blood glucose levels in diabetic mice, with

hypoglycemic effects comparable to metformin, and superior improvement in food and water intake. Conclusion: Compound 6 was

isolated from this plant for the first time. The compound 1, 5, 8-trihydroxy-3-methoxyxanthone significantly ameliorated the symptoms

of increased food and water intake in diabetic mice, exhibiting potent hypoglycemic activity. Given its high yield, it shows potential as a

natural antidiabetic drug or health product.

Total Synthesis of Indole Alkaloid Indiacen A

Luo Qianfei, , Wang Lihua, , Lei Ting, , Jiang Shizhi,

2024, 9(10): 6-12. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 002

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〔Abstract〕 Objective: The concise and efficient total synthesis of Indiacen A, an acyl indole compound with long isoprene chain, was

studied by 4-bromoindole as the starting material. Methods: The isoprene side chain was efficiently introduced through the Heck

dehydration reaction catalyzed by palladium, and the reaction conditions were optimized and screened. Results: The natural product

Indiacen A was synthesized by "one-pot method" with a high yield of 91% under optimal conditions. Conclusion: A synthesis strategy

of protecting-group-free and atom economy has been developed, which is simple to operate and has a high overall yield.

Multi-Index Optimization of Rape Pollen Granules Based on G1-Entropy Weight Method

Liu Zhu, Zou Chuncai, Chen Tao, Yan Haiyan

2024, 9(10): 13-19. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 003

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〔Abstract〕 Objective: To optimize the formulation of rape pollen granules by screening suitable moisture-proof excipients. Methods:

On the basis of pre-experiments, rape pollen extract was mixed with commonly used medicinal excipients. Using the forming rate,

angle of repose, and equilibrium moisture absorption rate of rape pollen particles as evaluation indicators, the comprehensive

evaluation index was calculated by the G1-entropy weight method. Then the optimal moisture-proof excipient prescription was

screened and the critical relative humidity was measured. Results: When the mass ratio of rape pollen extract, starch and mannitol was

1∶1.2∶0.8, the forming rate, angle of repose and equilibrium moisture absorption rate were 89.64%, 23.42°and 6.474 1%, respectively.

The comprehensive evaluation index was the highest, reaching 0.959 9. The critical relative humidity was 80%. Conclusion: The

moisture resistance of rape pollen granules based on G1-entropy weight method combined with multi-index optimization is satisfactory

and the process is stable and feasible, which can be used for the preparation of rape pollen granules.

Retrospective Analysis of Adverse Drug Reaction in a Tertiary Hospital

Deng Fuwen , Cao Fang , Long Song , Xu Yu , Yan Jinfang , Nie Yun

2024, 9(10): 20-25. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 004

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〔Abstract〕 Objective: To review and analyze adverse drug reaction （ADR） in a tertiary hospital, and to explore the characteristics

and rules of ADR, so as to provide reference for safer, effective and rational clinic drug use. Methods: 396 ADR reports reported to

National Center for ADR Monitoring, China from January to December 2022 were collected, and the ADR reports were retrospectively

analyzed. Results: Among the 396 ADR reports reported in the hospital, the probability ratio of ADR occurrence was 1：1 between

male and female, and the proportion of ADR occurrence was the highest in patients aged 45-64 years （154 cases, accounting for

38.89%）. Most reports were reported by doctors （290 cases, accounting for 73.23%）. Intravenous administration caused the most ADR

（273 cases, accounting for 68.94%）. The most ADR was caused by anti-infective drugs （158 cases, accounting for 39.90%）. The most

organs or systems involved in ADR were skin and its appendages （241 cases, accounting for 60.86%）. 99.75% （395/396） of ADR

patients improved or recovered after treatment. Conclusion: It is necessary to strengthen the training of ADR knowledge for clinicians

and nurses, so as to improve the awareness of ADR, the rates and quality of ADR reports, and to promote rational clinical drug use.

Antiproliferative Effect of Lichenic Acid on Pancreatic Cancer Cell Line PANC-1

Zhao Sen, Zhou Hua

2024, 9(10): 26-31. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 005

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〔Abstract〕 Objective: To explore the antiproliferative effect of lichenic acid on pancreatic cancer cell line PANC-1. Methods:

Lichenic acid was used to act on human PANC-1 cell, which was further followed by MTT assay to detect cell proliferative activity,

flow cytometry to detect the effect of lichenic acid on apoptosis of PANC-1 cell, scratch assay to detect the effect of lichenic acid on the

migration of PANC-1 cell, protein blotting to detect the expression of BAX, BCL2, and TrxR1 proteins, and enzyme labeling to detect

the enzymatic activity of TrxR1. Results: Lichenic acid reduced PANC-1 cell and promoted the apoptosis of PANC-1 cell, significantly

inhibited the migration of PANC-1 cell, up-regulated the expression of pro-apoptotic protein BAX, down-regulated the expression of

anti-apoptotic protein BCL2, and also inhibited the expression of TrxR1 and the activity of TrxR1 enzyme. Conclusion: Lichenic acid

could inhibit PANC-1 proliferation and is a potential chemotherapeutic agent for pancreatic cancer.

Application of Mind Mapping in Experimental Teaching of Human Parasitology

Lü Yan, Li Hailong, Du Shutong, Zhang Li

2024, 9(10): 32-35. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 006

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〔Abstract〕 Objective: To explore the feasibility, effect, and significance of using mind mapping in the experimental teaching of

human parasitology. Methods: Some randomly selected students from the 2020 grade of clinical medicine were divided into an

experimental group and a control group. In the experimental group, students were introduced to the experimental teaching by making

mind maps, explaining mind maps, and supplementing mind maps. In the control group, the traditional teaching method was adopted,

with teachers' lecturing as the main approach. Results: The questionnaire survey showed that the introduction of mind mapping

significantly improved students' learning enthusiasm and confidence, and enhanced their understanding of the content learned. The

analysis of the final experimental test scores showed that the experimental group （17.01±3.29） points performed better than the control

group （15.77±4.33） points, and the passing rate was also higher than the control group （χ2 =13.126, P＜0.01）. Conclusion: The

introduction of mind mapping can inspire medical students to engage in independent learning and promote the transformation and

internalization of knowledge.

Clinical Study on Biling Weitong Keli in the Treatment of Helicobacter pylori-Associated Gastritis

Zhou Feifei, Jiang Genhe

2024, 9(10): 36-39. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 007

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［关键词］慢性胃炎；幽门螺杆菌；四联疗法；荜铃胃痛颗粒；根除率

Analysis of Gene DPT Expression in Gastric Cancer Patients

Yang Cuiying , Chen Yiming

2024, 9(10): 40-43. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 008

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〔Abstract〕 Objective: To investigate the expression levels of gene DPT in gastric cancer tissues and tissues far away from cancer

lesions. Methods: Based on TCGA, Oncomine, and GEPIA databases, genes that might exhibit abnormal expression and are associated

with prognosis in gastric cancer tissues were identified. Gastric cancer tissues and far away from cancer lesions were collected, and the

expression levels of the target gene DPT were assessed using qRT-PCR and immunohistochemistry. Results: A total of 319

upregulated genes and 556 downregulated genes were identified, with gene DPT selected for further investigation. qRT-PCR and

immunohistochemistry results indicated that DPT expression was significantly lower in gastric cancer tissues compared to tissues far

away from cancer lesions, with a statistically significant difference （P<0.05）. Conclusion: There is a differential expression of gene

DPT between gastric cancer tissues and tissues far away from cancer lesions, which may be related to the occurrence of gastric cancer.

Further studies are needed to elucidate the specific mechanisms involved.

Effect of Ropivacaine Combined with Sufentanil on the Birth Process of Primiparas with Epidural

Analgesia in the Incubation Period of Labor

Yang Sili

2024, 9(10): 44-47. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 009

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〔Abstract〕 Objective: To explore the effect of self-controlled epidural analgesia with ropivacaine and sufentanil at different stages on

labor progression and delivery outcomes in primiparas. Methods: A total of 240 primiparas who underwent natural delivery at the

Department of Obstetrics at the First People's Hospital of Dali City from January to December 2021 were randomly divided into three

groups based on the timing of analgesia intervention: the incubation period analgesia group （group A）, the active phase analgesia group

（group B）, and the control group （group C）, with 80 cases in each group. Labor duration, maternal and neonatal outcomes, and

delivery conditions were compared among the three groups. Results: Significant differences were observed only in the duration of the

first stage of labor among the three groups （P<0.05）. Group A and group B showed significantly better results than group C in terms of

the time to initiation of lactation and visual analog scale （VAS） scores, with statistically significant differences （P<0.05）. Among the

three groups, group A had the highest rate of spontaneous vaginal delivery and the lowest rates of cesarean section, amniotic fluid

contamination, and lateral episiotomy, with statistically significant differences （P<0.05）. Conclusion: Epidural analgesia interventions

during labor have minimal impact on the labor process of primiparas undergoing natural delivery. Epidural analgesia administered

during the incubation period can significantly shorten labor duration, increase the rate of spontaneous vaginal delivery, reduce the

cesarean section rate, and improve pregnancy outcomes.

Investigation and Analysis of the Contamination Status of Bed Curtains in a Children's Hospital

Li Xiaojuan, , Li Yaling, , Li Weijie, , Han Yonghui, , Chen Liqin,

2024, 9(10): 48-51. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 010

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〔Abstract〕 Objective: To understand the contamination status of bed curtains in a children's hospital after washing and at different

times of use, and to provide a basis for establishing the frequency of curtain washing. Methods: A stratified random sampling method

was used to randomly select curtain samples from seven departments in the emergency department and general wards. Sampling was

carried out seven times, that was, immediately after washing, one week after use, and once per month from 1 month to 5 months after

use. The numbers of colonies were recorded. Results: There were statistically significant differences in contamination rates of curtains

among those used for different durations of usage, in different departments, and in different wards （P<0.05）. The contamination rate in

general wards was significantly higher than that in the emergency department. The number of colonies on the curtains in the internal

medicine department was the largest, and that in the emergency department was the smallest. Conclusion: The washed bed curtains

will be contaminated to varying degrees after one week of use, and the longer they are used, the more serious the contamination is. It is

necessary to regularly wash the curtains according to the contamination status, and increase the frequency of curtain washing for

departments with more severe contamination.

Clinicopathological Features of 22 Cases of Diffuse Large B-Cell Lymphoma Involving Bone Marrow

Shi Chengliang , Yin Jian , Pan Yun

2024, 9(10): 52-56. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 011

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〔Abstract〕 Objective: To investigate the clinicopathological features, treatment, and prognosis of patients with diffuse large B-cell

lymphoma （DLBCL） involving bone marrow, so as to improve the understanding and diagnostic accuracy of this disease. Methods: A

retrospective analysis was conducted on the medical records of 22 patients diagnosed with DLBCL involving bone marrow at the First

Affiliated Hospital of Dali University from January 2015 to June 2023. Hematoxylin and eosin staining, reticulin staining, and

immunohistochemical analysis were performed on bone marrow biopsy samples, and patients were classified into subtypes based on the

Hans algorithm. In addition, bone marrow hyperplasia, reticulin proliferation grading, and immunomarker expression were assessed. All

patients received R-CHOP chemotherapy and were followed up. Results: 10 patients showed bone marrow hypoplasia, while 19 patients

exhibited diffuse patchy or nodular distribution of the tumor. 16 patients had varying degrees of reticulin proliferation, predominantly at

MF-1 grade. CD20 and CD79α were highly positive, with the non-germinal center B-cell subtype being the most common. Conclusion:

Patients with DLBCL involving bone marrow have a severe condition and poor prognosis. Bone marrow biopsy is a crucial tool for both

diagnosis and prognosis.

Analysis of the Therapeutic Efficacy of F-RURS and mPCNL in the Treatment of Impacted Upper

Ureteral Stones

Liu Zhengli, Zheng Fei, Zou Jiulin, Zhang Aijian, Xiao Zhisong, Zheng Baoshou

2024, 9(10): 57-61. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 012

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〔Abstract〕 Objective: To investigate the clinical efficacy of F-RURS and mPCNL in the treatment of impacted upper ureteral stones.

Methods: A retrospective analysis of the medical records of 220 patients with impacted upper ureteral stones treated in the Department

of Urology of the First Affiliated Hospital of Dali University from January 2019 to January 2023 was conducted. Patients were divided

into the mPCNL group and the F-RURS group according to the treatment method. The surgical parameters, success rate of single

session stone fragmentation, stone clearance at 1 month postoperatively, and occurrence of postoperative complications were compared

between the two groups. Results: There was no statistically significant difference between the two groups in terms of surgery time and

stone clearance rate at 1 month postoperatively （P>0.05）. Compared with the mPCNL group, the F-RURS group had significantly

shorter postoperative hospital stay and less decrease in hemoglobin level postoperatively, with statistically significant differences （P<

0.01）. The stone fragmentation success rate in the mPCNL group was significantly higher than that in the F-RURS group, while the

incidence of postoperative complications was also significantly higher in the mPCNL group compared to the F-RURS group, with

statistically significant differences （P<0.01）. Conclusion: Both F-RURS and mPCNL can achieve satisfactory efficacy in the treatment

of impacted upper ureteral stones, with no serious postoperative complications in either group. F-RURS has the advantages of less

bleeding, shorter hospital stay, and lower incidence of postoperative complications, and is worth clinical promotion.

Diagnostic Value of Thin-Section CT in Discriminating the Nature of Pulmonary Nodules

Luo Xuelian , Zha Cheng , Yao Wenting , Sun Na , Zhu Shengkang

2024, 9(10): 62-66. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 013

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〔Abstract〕Objective: To explore the diagnostic value of thin-section CT imaging features in discriminating the nature of pulmonary

nodules. Methods: Clinical data of 100 patients with pulmonary nodules were retrospectively analyzed. Based on the pathological

examination results, they were divided into benign group and malignant group. All patients underwent thin-section CT imaging

examination. The nodular signs, grading assessment results, composition of thin-section CT imaging features, and thin-section CT

imaging indices were observed and compared between the two groups. The influence of each index on the diagnosis of benign and

malignant pulmonary nodules was discussed through Logistic regression analysis, and the diagnostic value of each index for benign and

malignant pulmonary nodules was analyzed by receiver operating characteristic curve （ROC curve）. Results: There were significant

differences between the two groups of patients in terms of pulmonary nodule grading system assessment results, thin-section CT imaging

features, and nodule-related indices （P<0.05）. The results of Logistic regression analysis showed that pulmonary nodule grading,

maximum nodule diameter, average CT value, and maximum CT value were independent factors affecting the diagnosis of malignant

pulmonary nodules （P<0.05）. With the increase of grading level and thin-section CT imaging-related indices, the risk of diagnosing

malignant pulmonary nodules increased. The ROC curve analysis results showed that pulmonary nodule grading, maximum nodule

diameter, average CT value, and maximum CT value all had clear diagnostic value in discriminating the nature of pulmonary nodules,

especially when used in combination. Conclusion: Thin-section CT imaging features have important clinical significance in

discriminating the nature of pulmonary nodules. Considering pulmonary nodule grading, maximum nodule diameter, average CT value,

and maximum CT value comprehensively can more accurately determine the nature of pulmonary nodules, providing more comprehensive

clinical reference for doctors.

Epidemiological and Clinical Characteristics of Brucellosis in the Dali Region

Huang Lihua, Li Nan, Luo Jiao, Gu Wei

2024, 9(10): 67-71. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 014

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〔Abstract〕 Objective: To analyze the epidemiological and clinical characteristics of brucellosis patients in the Dali region to provide

a theoretical basis for the diagnosis and treatment of brucellosis. Methods: A retrospective analysis was conducted on the data of 63

patients diagnosed with brucellosis at the First Affiliated Hospital of Dali University between January 1, 2013, and March 31, 2023.

Based on whether patients developed secondary thrombocytopenia, they were divided into a normal platelet group and a thrombocytopenia

group. Baseline data, laboratory results, and complications were compared between the two groups. Results: Among the 63 brucellosis

patients, 40 were male, and 23 were female, with an average age of （51.19±12.34） years. The most common initial clinical symptom was

fever, followed by lower back pain. The majority of the cases occurred between April and July. Patients in the thrombocytopenia group had

longer hospital stays and more severe conditions. Conclusion: In the Dali region, brucellosis is more common among middle-aged and

elderly men in rural areas with epidemiological exposure, with peak incidence occurring in spring and summer. Clinical manifestations

are diverse and complex, and patients with secondary thrombocytopenia experience more severe illness. Clinicians need to improve their

understanding of this disease to reduce missed and misdiagnosed cases.

Clinical Distribution Characteristics and Antibiotic Resistance Analysis of 509 Strains of

Haemophilus influenzae

Zhang Xuelin , Yang Yanling , Liu Lu , Zha Caijun,

2024, 9(10): 72-75. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 015

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〔Abstract〕 Objective: To investigate the clinical distribution characteristics and antibiotic resistance of

Haemophilus influenzae

Baoshan, in order to guide rational clinical drug use.

Methods: A total of 509 non-duplicate strains of Haemophilus influenzae

were

collected from Baoshan People's Hospital between 2018 and 2022. Species identification was performed using a microbial mass

spectrometry rapid identification system, and drug susceptible test was conducted using

Haemophilus influenzae drug susceptibility

testing kits. Data were analyzed using SPSS 26. 0 and Whonet 5.6 software.

Results: The 509 strains of Haemophilus influenzae were

primarily isolated from respiratory specimens such as sputum, nasopharyngeal secretions, and bronchoalveolar lavage fluid. The main

infected populations were children aged 0-12 years and elderly individuals over 60 years of age. No strains were found to be resistant to

piperacillin/tazobactam, meropenem, imipenem, or levofloxacin. Low resistance rates were observed for ceftriaxone, ceftazidime,

cefepime, aztreonam, and ciprofloxacin. However

, high resistance rates were found for ampicillin

, cefuroxime, and compound

sulfamethoxazole. A comparison between

β -lactamase-negative and

β -lactamase-positive strains showed significant differences in

resistance rates to all tested antibiotics except ceftriaxone and ciprofloxacin （

P<0.05）

. Similarly, significant differences in resistance

rates were observed between elderly individuals over

60 years and children aged 0-12 years for all tested antibiotics except

ciprofloxacin （

P<0.05）

. Conclusion: The clinical distribution and antibiotic resistance of

Haemophilus influenzae

vary significantly.

Individualized treatment regimens should be developed based on the specific conditions of the patients.

Research on the Role of "Four-Prevention" System in Prevention and Control of Hospital Infection

Yang Sulian , He Yinlai , Yang Qijuan , Wang Yuan , Yang Chunfang , Li Jiangtao , Li Cairui

2024, 9(10): 76-79. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 016

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〔Abstract〕 Objective: To explore the role of the construction of organizational system, people management, apparatus management

and technique support （hereinafter referred to as "four-prevention" system） in the control of hospital infection.

Methods: The hospital

infection data of the First Affiliated Hospital of Dali University in

2019 and 2021 were collected and analyzed by the real-time monitoring

system of Xinglin Hospital Infection.

Results: The relative measures of hospital infection prevention and control increased significantly

in 2021 compared with

2019, with the highest growth rate of 914.29%. Compared with 2019

, the incidence of hospital infection in

2021

decreased （

P<0.05）

, the number of hospital infection positive strains decreased by

16.12

%, the number of carbapenem-resistant

organism （CRO） decreased by 70.44%, the number of carbapenem-resistant Enterobacteriaceae decreased by

42.31%, and the number

of CRO cases in ICU and EICU decreased by 63.89%.

Conclusion: Strengthening the construction of "four-prevention" system can

effectively reduce the incidence of hospital infection, and has a targeted effect on the prevention and control of CRO.

Psychological Status and Influencing Factors of Rural Doctors in Dali Bai Autonomous

Prefecture under the COVID-19 Pandemic

He Zuo , Yang Ruixue , Li Wanying , He Sheji , Zuo Lijuan , Shi Zhaoyun

2024, 9(10): 80-84. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 017

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〔Abstract〕 Objective: To investigate the psychological status and influencing factors of rural doctors in Dali Bai Autonomous

Prefecture （hereinafter referred to as "Dali Prefecture"） during the prevention and control of COVID-19 pandemic.

Methods: A self

made basic information questionnaire and the Depression Anxiety Stress Scale-

21（

DASS-21） were used to conduct an online survey

of 463 rural doctors in Dali Prefecture via Wenjuanxing platform.

Results: The incidence rates of depression

, anxiety and stress were

12.74% （59/463）

, 24.41% （113/463） and 7.13% （33/463）

, respectively. Multivariate Logistic regression analysis showed that age

and health status were the influencing factors of depression, anxiety and stress （

P<0.05）

, and younger age and poor health status were

the risk factors of psychological status. In addition, ethnicity was another influencing factor of stress

（

P<0.05）

, and Han rural doctors

were 2.759 times more stressed than minority rural doctors.

Conclusion: The psychological condition of rural doctors in Dali Prefecture

under the COVID-19 pandemic has been affected to a certain extent, and measures such as mental health consultation and intervention

should be taken in a timely manner, and focused attention should be given according to the incidence and its influencing factors.

Status and Influencing Factors of Body Image Disturbance in Patients with Primary Brain Tumor

Yao Qianqian , Liu Li , Luo Yanfang

2024, 9(10): 85-91. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 018

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〔Abstract〕 Objective: To investigate the status and influencing factors of body image disturbance in patients with primary brain

tumor, and to provide theoretical support for clinical intervention.

Methods: Convenience sampling method was used to select primary

brain tumor patients hospitalized in the neurosurgery department of a tertiary hospital in Kunming from December 2020 to August 2021

for questionnaire survey. The questionnaire included gerneral demographic questionnaire, Body Image Scale, Resilience Scale-14,

Medical Coping Modes Questionnaire, Perceived Social Support Scale. Multiple linear stepwise regression analysis was used to

investigate the influencing factors of body image disturbance in patients with primary brain tumor

Results: The body image score of

226 patients with primary brain tumors was 5.00（

3.00, 9.00） points, 88.5% of the patients had body image disturbance, and 22.1% of

the patients had severe body image disturbance. Social support, psychological resilience, literacy level, avoidance coping strategy

gender and tumor grade were the independent influencing factors of body image disturbance in patients with primary brain tumor

（

0.05）

Conclusion: The current situation of body image disturbance in patients with primary brain tumor is serious. According to the

influencing factors, clinical workers should take intervention strategies to improve the problem of body image disturbance and promote

the physical and mental health of patients.

Application of Key Performance Indicator in Performance Evaluation of Nursing Staff in a Hospital

Dong Wei, Duan Pengyuan, Lu Huixia

2024, 9(10): 92-96. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 019

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〔Abstract〕 Objective: To explore the application effects of key performance indicator （KPI） in the performance evaluation of nursing

staff in the department of internal medicine and surgery of the First Affiliated Hospital of Dali University

Methods: The KPI method

was applied to evaluate the performance of 35 departments in the hospital with 5 KPI indicators （including 16 sub-indicators）

, such as

nursing quality, nursing defect management, patient service, personal learning and growth of nurses

, and additional points. The

comprehensive nursing qualities before and after the implementation of KPI were compared.

Results: After the implementation of KPI

nursing safety, writing quality of nursing documents, management of emergency drugs and supplies, correct implementation rate of safe

injection and awareness rate of health education in the internal medicine section were significantly improved （

P<0.05）

, while the

implementation rate of checking system and correct implementation rate of safe injection in the surgical area were significantly

improved （

P<0.05）

. Hospitalized patients' satisfaction with nursing work was significantly improved （P<0.05）

. Both the number of

adverse events and the incidence of medication errors in the department of internal medicine and surgery were decreased. The passing

rate of medical nurses in theoretical examination and the passing rate of the theory and skill examination of surgical nurses were

significantly improved （

P<0.05）

. Conclusion: The application of KPI in nursing staff performance evaluation can effectively evaluate

and improve the nursing quality of each clinical department, improve the satisfaction of patients, and significantly improve the personal

ability of nurses.

Design and Application Effects of Nursing Internship Syllabus from the Perspective of Teaching Hospitals

Zhang Li, He Haiyan, Qi Guangcheng, Yang Jinmei, Liu Xiaoying, Kong Guifen

2024, 9(10): 97-100. DOI: ［DOI］10. 3969 / j. issn. 2096-2266. 2024. 10. 020

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〔Abstract〕 Objective: To explore the application effects of internship syllabus designed from the clinical perspective of hospitals on

internship nursing students

Methods: 103 nursing students who interned at the Fourth Affiliated Hospital of Dali University were

selected as the research subjects. 52 students who interned from July 2021 to March 2022 were set as the control group, while 51

students who interned from July 2022 to March 2023 were set as the observation group. The control group used the internship syllabus

prepared by the school, while the observation group used the syllabus designed by the nursing teaching and research faculty of the

hospital. The academic performance and satisfaction with teaching of two groups were compared and analyzed.

Results: The theoretical

and operational scores, and the satisfaction of internship nursing students in the observation group were better than those in the control

group, and the differences were statistically significant（

P<0.05）

. Conclusion: The nursing internship syllabus designed from the

perspective of teaching hospitals has a significant application effect in clinical internships of nursing students, which is beneficial for

improving their professional abilities and improving their satisfaction with teaching.