乳腺癌超声征象与cerbB-2、Ki67、P53表达之间的相关性研究

摘要/Abstract

摘要：

目的：探讨乳腺癌超声图像特征与cerbB-2、Ki67、P53表达的相关性及临床意义。方法：回顾性分析经病理证实的165
例乳腺癌病例，其彩色多普勒超声表现与病理切片免疫组化染色检测cerbB-2、Ki67、P53的表达水平。结果：①肿块直径大
小、肿块血流分级与Ki67表达呈正相关（P＜0.05）。②毛刺征、后方回声衰减与cerbB-2表达呈负相关（P＜0.05）。③Ki67表
达的相关危险因素是血流分级，血流分级为Ⅱ~Ⅲ级的肿块，其Ki67的表达明显增多，且分级为Ⅱ~Ⅲ级的血流形态为内部血
流和穿支血流，并以穿支血流为主。④周边高回声晕、肿块内部微钙化、淋巴结转移和血流分布形态与cerbB-2、Ki67和P53的
表达均无相关性。结论：乳腺癌的超声表现与cerbB-2和Ki67表达之间有一定的相关性，二者结合分析为乳腺癌的临床诊断、
治疗及预后提供重要依据。

关键词: 乳腺癌, 超声征象, 人类上皮生长因子受体2, 增殖细胞核抗原, 抑癌基因

Abstract:

Objective：To research the correlation of ultrasound features with the expressions of cerbB-2, Ki67 and P53 in breast
carcinoma and evaluate the clinical application value. Methods: 165 cases of breast carcinoma confirmed by pathologic proofs were
retrospectively analyzed. The ultrasound features and results of specimens stained for cerbB-2, Ki67 and P53 with immunohistochemical
method were studied. Results: ①There was a positive correlation between the diameter of breast carcinoma,the blood flow grade, and
the expression of Ki67（P＜0.05）. ② There was a negative correlation between spicular signs, posterior echo attenuation, and the
expression of cerbB-2（P＜0.05）.③The risk factor related to Ki67 expression was the grade of blood. The expression of Ki67 increased
significantlyinbreast carcinoma with the blood flow grade Ⅱ-Ⅲ. GradeⅡ-Ⅲ often showed central and penetrating vascularity patterns,
with the latter dominating. ④There was not a correlation between peripheral acoustic halo, micro-calcification, the axillary lymph nodes
metastasis，vascularity patterns of breast carcinoma, and the expressions of Ki67, P53,cerbB-2. Conclusion: Ultrasound performance of
breast carcinoma has relevance with cerbB-2 and Ki67 expressions.The combined analysis of the above mentioned factors can provide
clinical application valuein diagnosis , treatment and prognosis of breast carcinoma.

Key words: breast carcinoma, ultrasonography, biologic factors cerbB-2, Ki67, P53

中图分类号:

R445.1

曹亚，杨丽春. 乳腺癌超声征象与cerbB-2、Ki67、P53表达之间的相关性研究[J]. J4, 2016, 1(8): 70-75.

CaoYa,Yang Lichun. Correlation of Ultrasound Morphologic Features with the Expressions of CerbB-2,Ki67 and
P53 in Breast Carcinoma[J]. J4, 2016, 1(8): 70-75.

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