大理大学学报 ›› 2019, Vol. 4 ›› Issue (2): 59-.

• 临床医学 • 上一篇    下一篇

康柏西普治疗糖尿病视网膜病变及其伴发黄斑水肿的#br# 临床应用研究

程飞,贾云琴,韩佩宴,陈银朝,周霞,段直光   

  1. (1. 大理大学临床医学院,云南大理671000;2.大理大学第三附属医院眼科,云南大理671000)
  • 收稿日期:2018-09-21 修回日期:2018-12-07 出版日期:2019-02-15 发布日期:2019-02-15
  • 通讯作者: 段直光,主任医师,E-mail:dzgdl@sina.com.
  • 作者简介:程飞,硕士研究生,主要从事眼底病变研究.
  • 基金资助:
    大理州科技计划资助项目(D2017SA02)

Clinical Application of Conbercept for Treatment of Diabetic Retinopathy and Macular Edema

Cheng Fei, Jia Yunqin, Han Peiyan, Chen Yinchao, Zhou Xia, Duan Zhiguang   

  1. (1. Clinical College, Dali University, Dali, Yunnan 671000, China; 2. Ophthalmology Department, The Third Affiliated Hospital of Dali
    University, Dali, Yunnan 671000, China)
  • Received:2018-09-21 Revised:2018-12-07 Online:2019-02-15 Published:2019-02-15

摘要: [摘要]目的:评价玻璃体腔注射康柏西普(Conbercept)治疗糖尿病视网膜病变(DR)的有效性、安全性及对增殖型糖尿病视网
膜病变(PDR)玻璃体切除术的影响。方法:回顾性分析在大理大学第三附属医院接受玻璃体腔注射康柏西普的各种DR患者
56例(80眼),其中非增殖性糖尿病视网膜(NPDR)患者30例(52眼),严重增殖性糖尿病视网膜病变(PDR)患者26例(28眼)进
行玻璃体切除(PPV),随机分为术前玻璃体腔注射康柏西普联合玻璃体切除术组(IVC/PPV组)15例(16眼)和单纯PPV组11
例(12眼)。结果:NPDR患者眼底病变不同程度获得改善,新生血管明显得到抑制,黄斑水肿有一定的改善、吸收,最佳矫正视
力(BCVA)有不同程度提高。IVC/PPV组明显有利于手术操作。结论:玻璃体腔注射康柏西普治疗NPDR疗效显著,对拟行玻
璃体切除的严重PDR患者,能有效降低手术难度,减少手术并发症的发生,是糖尿病视网膜病变治疗的主流选择。

关键词: [关键词]康柏西普, 糖尿病视网膜病变, 应用研究

Abstract: 〔Abstract〕Objective: To evaluate the efficacy and safety of Conbercept intravitreal injections in treatment of diabetic retinopathy,
and its effects on vitrectomy for proliferative diabetic retinopathy(PDR). Methods: We retrospectively analyzed 56 patients(80 eyes)
with DR who received Conbercept intravitreal injection in our hospital. 30 patients(62 eyes)had NPDR, and 26(28 eyes)with severe
PDR underwent vitreous resection(PPV). The latter was randomly divided into the IVC&PPV group in which 15 patients(16 eyes)
were treated with conbercept intravitreal injection in combination with vitrectomy and the PPV group in which 11patients(12 eyes)
underwent vitrectomy. Results: Among patients with NPDR, their diabetic retinopathy was improved in varying degrees,
neovascularization was significantly inhibited, macular edema was improved and absorbed, and visual acuity was corrected in different
degrees. IVC/PPV was significantly favorable for surgical operations. Conclusion: Intravitreal injection of Conbercept is an effective
treatment for NPDR. For severe PDR patients who are undergoing vitrectomy, it can effectively reduce the difficulty of surgery and
reduce the occurrence of surgical complications, so it is the mainstream choice for the treatment of diabetic retinopathy.

Key words: 〔Key words〕Conbercept, diabetic retinopathy, applied research