关键词:

"> font-size:10.5pt, ">抗逆转录病毒药, 艾滋病, 焦虑, 抑郁, 睡眠障碍

Abstract:

Objective：To analyze the occurrence of anxiety， depression and sleep disorders in HIV/AIDS patients treated with antiretroviral therapy and analyze the influencing factors. Methods： Questionnaires were administered to 1 200 HIV/AIDS patients attending Kunming Third People's Hospital from Decembor 2021 to March 2022. The questionnaires used the Hospital Anxiety and Depression Scale and the Pittsburgh Sleep Quality Index to investigate anxiety， depression and sleep disorders in HIV/AIDS patients receiving different antiretroviral treatment regimens. Univariate analysis and multifactorial Logistic regression analysis were used to analyze the factors influencing patients' anxiety， depression and sleep disorders. Results： The prevalence of anxiety， depression， and sleep disorders in 1 200 HIV/AIDS patients was 24.9%， 30.7%， and 39.2%， respectively， and 11.0% had concurrent anxiety， depression， and sleep disorders， and 20.6% had combined anxiety and depression. The results of multifactorial Logistic regression analysis showed that male, having a stable job, treatment time less than 3 months were the protective factors of anxiety, and receiving efavirenz treatment was a risk factor of anxiety; male and having a stable job were the protective factors of depression, and receiving treatment regimens containing non-nucleoside reverse transcriptase inhibitors and protease inhibitors were the risk factors of depression; having a stable job was a protective factor of sleep disorders, and receiving treatment regimens containing non-nucleoside reverse transcriptase inhibitors and protease inhibitors were the risk factors of sleep disorders. Conclusion： The incidence of anxiety， depression and sleep disorders in HIV/AIDS patients is more seriously affected by antiretroviral therapy. The incidence of neuropsychotoxic side effects of integrase inhibitors is lower than that of non-nucleoside reverse transcriptase inhibitors and protease inhibitors， and the monitoring of patients' mental status should be strengthened to optimize the protocol according to patients' conditions.

Key words:

"> font-size:10.5pt, ">antiretroviral drugs, AIDS, anxiety, depression, sleep disorders