J4 ›› 2012, Vol. 11 ›› Issue (12): 20-23.

• 基础医学 • 上一篇    下一篇

结核分枝杆菌ESX-1分泌系统的研究进展

目的:综述结核分枝杆菌ESX-1分泌系统的组成及其组分的作用。方法:检索并查阅结核分枝杆菌ESX-1分泌系统相关
的文献,并进行归纳总结。结果:ESX-1系统是以分泌ESAT-6及CFP-10为特征的分泌系统,包括编码基因及十余种分泌调节基
因。结论:结核分枝杆菌毒力分子ESAT-6及CFP-10的分泌是多种相关编码基因共同作用的结果。   

  1. 大理学院基础医学院,云南大理 671000
  • 收稿日期:2012-09-20 修回日期:2012-11-05 出版日期:2012-12-15 发布日期:2012-12-15
  • 作者简介:邓仪昊,讲师,博士,主要从事免疫机制研究.
  • 基金资助:

    大理学院博士科研启动基金(KYBS201103)

Research Progress of ESX-1 Secretion System of Mycobacterium tuberculosis

Objective: To review components and their functions of ESAT-6 secretion system-1 (ESX-1)of Mycobacterium
tuberculosis. Methods: Consult and summarize related reference material about ESX -1 secretion system of Mycobacterium
tuberculosis. Results: ESX-1 secretion system is characterized by secretion of ESAT-6 and CFP-10, including coding genes and
more than ten secretive regulator genes. Conclusion: The secretions of virulence factor of ESAT-6 and CFP-10 in Mycobacterium
tuberculosis were controlled by multiple related encoding genes.   

  1. Pre-clinical College, Dali University, Dali, Yunnan 671000, China
  • Received:2012-09-20 Revised:2012-11-05 Online:2012-12-15 Published:2012-12-15

摘要:

目的:综述结核分枝杆菌ESX-1分泌系统的组成及其组分的作用。方法:检索并查阅结核分枝杆菌ESX-1分泌系统相关
的文献,并进行归纳总结。结果:ESX-1系统是以分泌ESAT-6及CFP-10为特征的分泌系统,包括编码基因及十余种分泌调节基
因。结论:结核分枝杆菌毒力分子ESAT-6及CFP-10的分泌是多种相关编码基因共同作用的结果。

关键词: 结核分枝杆菌, ESX-1分泌系统, ESAT-6, CFP-10

Abstract:

Objective: To review components and their functions of ESAT-6 secretion system-1 (ESX-1)of Mycobacterium
tuberculosis. Methods: Consult and summarize related reference material about ESX -1 secretion system of Mycobacterium
tuberculosis. Results: ESX-1 secretion system is characterized by secretion of ESAT-6 and CFP-10, including coding genes and
more than ten secretive regulator genes. Conclusion: The secretions of virulence factor of ESAT-6 and CFP-10 in Mycobacterium
tuberculosis were controlled by multiple related encoding genes.

Key words: Mycobacterium tuberculosis, ESX-1 secretion system, ESAT-6, CFP-10

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