J4 ›› 2013, Vol. 12 ›› Issue (6): 1-4.

• 药学 •    下一篇

毛大丁草根水煎剂对受试动物的镇咳、祛痰、平喘作用

  

  1. 大理学院药学与化学学院,云南大理 671000
  • 收稿日期:2013-03-05 修回日期:2013-03-22 出版日期:2013-06-15 发布日期:2013-06-15
  • 作者简介:郭美仙,实验师,主要从事中药药理学研究.
  • 基金资助:

    大理州科技局科研基金资助项目(2060402);大理学院大学生科研基金资助项目(DXSKYY201123)

Effect of Gerbera piloselloides Decoction on Preventing Cough, Eliminating Phlegm and Relieving Asthma on Mice

  1. College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China
  • Received:2013-03-05 Revised:2013-03-22 Online:2013-06-15 Published:2013-06-15

摘要:

目的:观察毛大丁草根水煎剂对受试动物的镇咳、祛痰、平喘作用。方法:采用氨水诱咳法分别观察毛大丁草根水煎剂对
小鼠咳嗽次数及咳嗽潜伏期的影响;酚红排泌法检测毛大丁草根水煎剂对小鼠呼吸道酚红排泌量的影响;离体气管法观察毛大
丁草根水煎剂对乙酰胆碱(Ach)、组胺(His)诱导的豚鼠离体气管平滑肌收缩的影响。结果:毛大丁草根水煎剂可减少小鼠咳嗽
次数、延长咳嗽潜伏期;可增加小鼠呼吸道酚红排泌量;可降低Ach、His诱导的豚鼠离体气管平滑肌的收缩张力。结论:毛大丁草
根水煎剂对受试动物具有镇咳、祛痰、平喘作用。

关键词: 毛大丁草根, 水煎剂, 镇咳, 祛痰, 平喘

Abstract:

Objective: To observe the effects of antitussive, expectorant and anti-asthmatic of Gerbera piloselloides(L.)cass root on
the experimental animals. Methods: Mouse cough model was induced by ammonia water, the times and incubation period of cough on
mice was recorded. The phenol red excretion test was applied to detect the amount of phenol red excreted by respiratory tract, and the
guinea pig tracheal in vitro was adopted to record the effect of contractive tension of the isolated tracheal smooth muscle induced by
acetylcholine(Ach)and histamine(His). Results: Data showed that the decoction extracted from the Gerbera piloselloides(L.)cass
root could reduce the cough times, prolong the cough incubation period of the mice, increase the amount of phenol red excreted by
respiratory tract; and reduce the tension of contraction of isolated tracheal smooth muscle induced by Ach and His. Conclusion: The
water decoction from Gerbera piloselloides(L.)cass root has effects of preventing cough, eliminating phlegm and relieving asthma on
experimental cough animal.

Key words: Gerbera piloselloides(L.)cass root, water decoction, antitussiveexpectorantanti-asthmatic

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