隔山消对小鼠小肠推进作用的研究

J4 ›› 2015, Vol. 14 ›› Issue (4): 5-7.

隔山消对小鼠小肠推进作用的研究

1. 大理学院基础医学院，云南大理671000；2.云南省昆虫生物医药研发重点实验室，云南大理671000；
3. 楚雄医药高等专科学校，云南楚雄675000；4. 大理学院药学与化学学院，云南大理671000

收稿日期:2014-12-17 出版日期:2015-04-15 发布日期:2015-04-15
作者简介:耿玲，助理实验师，主要从事病原微生物学研究.
基金资助:
大理学院青年教师科研基金资助项目（KYQN201309）

Effect of the Extracts from Geranium strictipes R. Knuth on the Intestinal Propulsion Function in Mice

1. Pre-clinical College, Dali University, Dali, Yunnan 671000, China; 2. Yunnan Provincial Key Laboratory of Entomological
Biopharmaceutical R＆D, Dali, Yunnan 671000, China; 3. Chuxiong Pharmaceutical College, Chuxiong, Yunnan 675000, China;
4. College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China

Received:2014-12-17 Online:2015-04-15 Published:2015-04-15

摘要/Abstract

摘要：

目的：初步探讨隔山消乙酸乙酯提取物对小鼠小肠推进功能的影响。方法：对正常小鼠以及阿托品诱导的小肠功能抑
制小鼠给予隔山消乙酸乙酯提取物，通过测定不同实验组炭末混悬液在小肠中的推进距离，评价隔山消乙酸乙酯提取物对小
肠推进功能的影响。结果：隔山消乙酸乙酯提取物各剂量组均能明显提高正常小鼠小肠炭末推进率，其中高剂量组的作用最
为明显，推进率达到了75.93%；隔山消乙酸乙酯提取物各剂量组还能提高阿托品抑制的小鼠小肠炭末推进率，以低剂量作用
最好，推进率达到了43.28%。结论：隔山消乙酸乙酯提取物可以明显促进小肠运动，并能对抗阿托品所致的小鼠小肠功能障
碍，这可能与M胆碱受体有关。

关键词: 隔山消乙酸乙酯提取物, 小肠推进, 炭末, 阿托品

Abstract:

Objective: To study the effect of the ethyl acetate extract from Geranium strictipes R. Knuth（EAEG）on the intestinal
propulsion function in mice. Methods: Normal mice and mice of intestinal function inhibited by atropine were given different doses
EAEG for continuous 4 days, finally the propulsion distance of carbon in intestinal was measured. Results: EAEG-L（50 mg/kg）,
EAEG-M（100 mg/kg）and EAEG-H（200 mg/kg）all could increase the propulsion rate in normal mice, even the figure is up to
75.93% in EAEG-H group; in addition, EAEG-L（50 mg/kg）could improve apparently intestinal carbon propulsion rate which is
43.28%. Compared with control group, the difference is statistically significant. Conclusion: The acceleration of EGEG on intestinal
movement in normal mice and mice intestinal-inhibited by atropine may be related with M receptor.

Key words: EAEG, intestinal propulsion, carbon, atropine

中图分类号:

R284.3

耿玲，李洪文，陈俊雅，李辉. 隔山消对小鼠小肠推进作用的研究[J]. J4, 2015, 14(4): 5-7.

Geng Ling, Li Hongwen, Chen Junya, Li Hui. Effect of the Extracts from Geranium strictipes R. Knuth on the Intestinal Propulsion Function in Mice[J]. J4, 2015, 14(4): 5-7.

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