西地那非治疗先天性心脏病相关肺动脉高压27例临床观察

J4 ›› 2015, Vol. 14 ›› Issue (10): 17-19.

西地那非治疗先天性心脏病相关肺动脉高压27例临床观察

大理大学附属医院，云南大理671000

收稿日期:2015-03-10 出版日期:2015-10-15 发布日期:2015-10-15
作者简介:董榆，副主任医师，主要从事心血管内科研究.

Clinical Observation of Sildenafil Treating Pulmonary Arterial Hypertension in 27 Patients with
Congenital Heart Disease

Affliated Hospital of Dali University, Dali, Yunnan 671000, China

Received:2015-03-10 Online:2015-10-15 Published:2015-10-15

摘要/Abstract

摘要：

目的：观察西地那非对先天性心脏病患者心功能及先天性心脏病相关肺动脉高压的影响。方法：对27例先天性心脏病
并发肺动脉高压患者在常规治疗基础上加用西地那非，20 mg/次，3 次/d。结果：经西地那非治疗后，心功能及平均肺动脉压力
显著改善（P＜0.01）。结论：西地那非可改善先天性心脏病患者心功能及降低相关肺动脉高压。

关键词: 西地那非, 先天性心脏病, 相关肺动脉高压

Abstract:

Objective: To study the effect of sildenafil treating pulmonary arterial hypertension in patients with congenital heart
disease. Methods: Twenty-seven patients with congenital heart disease complicated with pulmonary arterial hypertension were treated
with sildenafil at 20 mg each time, 3 times a day. Results: Sildenafil significantly improved heart function and mean pulmonary artery
pressure（P＜0.01）. Conclusion: Sildenafil improves cardiac function in patients with congenital heart disease and reduces the
associated pulmonary arterial hypertension.

Key words: sildenafil, congenital heart disease（CHD）, pulmonary arterial hypertension（PAH）

中图分类号:

R541.1

董榆. 西地那非治疗先天性心脏病相关肺动脉高压27例临床观察[J]. J4, 2015, 14(10): 17-19.

Dong Yu. Clinical Observation of Sildenafil Treating Pulmonary Arterial Hypertension in 27 Patients with
Congenital Heart Disease[J]. J4, 2015, 14(10): 17-19.