Validation Study of Xpert MTB/RIF in Diagnosis of Pulmonary Tuberculosis and Detection of Rifampicin Resistance

doi:10. 3969/j. issn. 2096-2266. 2021. 10. 014

Abstract

Abstract:

Objective： By comparing the difference between Xpert MTB/RIF technology and proportional drug sensitivity test in the detection rates of Mycobacterium tuberculosis（MTB）， the application effects of the two methods on the detection of MTB and rifampicin resistance were evaluated. Methods： Xpert MTB/RIF detection， strain identification and proportional drug sensitivity test were performed on 546 cases of pulmonary tuberculosis and suspected patients with positive sputum culture specimens to evaluate the sensitivity， specificity and 95%CI of Xpert MTB/RIF detection. Results： In the drug sensitivity test， the total resistance rate of anti-tuberculosis drugs in initial treatment patients was 3.01% and that of rifampicin was 2.31%； the total resistance rate of anti-tuberculosis drugs in retreated patients was 76.47%， and that of rifampicin was 11.76%. The sensitivity of Xpert MTB/RIF for rifampicin resistance was 97.50% and the specificity was 97.41%. Conclusion： Xpert MTB/RIF has extremely high sensitivity and specificity in the diagnosis of pulmonary tuberculosis and the detection of rifampicin resistance， and it has great consistency with the proportional method. It is a rapid and effective method for the diagnosis and drug resistance screening of pulmonary tuberculosis.

Key words: font-family:", ">Xpert MTB/RIFfont-family:宋体, ">；font-family:", "> Mycobacterium tuberculosisfont-family:宋体, ">；font-family:", "> rifampicin

CLC Number:

R521

Zhang Jinglan, Chen Ran.

Validation Study of Xpert MTB/RIF in Diagnosis of Pulmonary Tuberculosis and Detection of Rifampicin Resistance [J]. Journal of Dali University, 2021, 6(10): 63-.

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