关键词: 美洲大蠊, 抗疲劳, 耐缺氧, 免疫调节, 小鼠

Abstract:

Objective: To observe the effects of Periplaneta americana on immune function and anti-fatigue. Methods: Mice were
divided into 5 groups randomly, which were positive control group, blank control group and Periplaneta americana low, medium and
high dose groups, the exhaustive swimming time, the activity of lactic dehydrogenase（LDH）in the blood after swimming 3 h, the
survival time under normal pressure accompanying with anoxic conditions, the viscera index, the carbon clearance index（K）and the
immune organ quality index（α）were measured. Results: Compared with the blank control group, the dose group had found that the
survival time and the swimming time prolonged, the LDH activity of blood increased, the viscera index increased, the K and α both
improved. Compared with the positive control group, the high dose group significantly prolonged the survival time of mice, the high
dose group and middle dose group significantly increased the exhaustive swimming time, the blood LDH activity of the high dose group
increased significantly, the K and α of high dose group had improved significantly. Conclusion: Periplaneta americana has the effects
of enhancing immunity and resisting fatigue.

Key words: Periplaneta americana, antifatigue, hypoxia tolerance, immune regulation, mice