大理大学学报 ›› 2022, Vol. 7 ›› Issue (2): 57-61.

• 临床医学 • 上一篇    下一篇

阴道微环境及白介素-4与宫颈高危型人乳头状瘤病毒感染的相关研究

周源源,杜凌颖,齐梦娟,郭 颖*   

  1. (大理大学第一附属医院,云南大理 671000)

  • 收稿日期:2020-09-30 修回日期:2021-03-14 出版日期:2022-02-15 发布日期:2022-03-29
  • 通讯作者: 郭颖,住院医师,E-mail:519694096@qq.com。
  • 作者简介:周源源,住院医师,主要从事围产医学及妇科肿瘤研究。
  • 基金资助:
    云南省教育厅科学研究基金项目(2020J0572);大理市科技计划项目(2019KGB019);大理大学青年教师科学研究基金项目(KYQN201517)

Study on the Relationship between Vaginal Microenvironment, Interleukin-4 and High-Risk HPV Infection of the Cervix

Zhou Yuanyuan, Du Lingying, Qi Mengjuan, Guo Ying*   

  1. (The First Affiliated Hospital of Dali University, Dali, Yunnan 671000, China)

  • Received:2020-09-30 Revised:2021-03-14 Online:2022-02-15 Published:2022-03-29

摘要: 目的:研究阴道微环境及白介素-4(IL-4)与宫颈高危型人乳头状瘤病毒(HR-HPV)感染的关系。方法:选取2018年12月至2019年12月大理大学第一附属医院就诊的宫颈HR-HPV感染的育龄期患者85例为观察组(A组),同期体检宫颈HPV阴性者83例为对照组(B组)。比较不同年龄段女性感染HR-HPV情况,检测阴道微环境及阴道灌洗液中IL-4水平,分析HR-HPV感染与常见阴道炎的关系,并进行多变量Logistic回归分析。结果:HR-HPV感染者中,年龄≤25岁及>45岁者感染率较26~45岁者高,差异有统计学意义(P<0.05);A组与B组阴道微环境相关指标和阴道灌洗液中IL-4水平比较差异有统计学意义(P<0.05);A组滴虫性阴道炎和细菌性阴道病阳性率高于B组,差异有统计学意义(P<0.05);Logistic回归分析结果显示,乳酸杆菌、滴虫性阴道炎、细菌性阴道病、白细胞酯酶均是HR-HPV感染的独立危险因素。结论:HR-HPV感染存在年龄分布特点,阴道微环境及阴道灌洗液中IL-4水平升高与其分型密切相关。

关键词: font-family:SimSun, ">"> , font-family:SimSun, ">阴道微环境;阴道菌群;白介素font-family:SimSun, ">-4font-family:SimSun, ">;高危型人乳头状瘤病毒

Abstract:

Objective: To study the relationship between vaginal microenvironment, interleukin-4(IL-4) and high-risk human papilloma virus(HR-HPV) infection of the cervix. Methods: From December 2018 to December 2019, 85 patients of childbearing age with cervical HR-HPV infection who were admitted to the First Affiliated Hospital of Dali University were selected as the observation group(Group A), and 83 patients with cervical HPV-negative physical examination during the same period were selected as the control group(Group B). The HR-HPV infections in women of different ages were compared, the vaginal microenvironment and the level of IL-4 in vaginal lavage fluid were detected, and the relationship between HR-HPV infection and common vaginitis was analyzed by multivariate Logistic regression analysis. Results: Among HR-HPV infected persons, the infection rate of persons ≤25 years old and >45 years old was higher than that of persons 26 to 45 years old, and the difference was statistically significant (P<0.05). There were significant differences in vaginal microenvironmental indicators and the level of IL-4 in vaginal lavage fluid between Group A and Group B(P<0.05). The positive rates of trichomonas vaginitis and bacterial vaginosis in Group A were higher than those in Group B, and the differences were statistically significant(P<0.05). Logistic regression analysis showed that Lactobacillus,trichomonas vaginitis, bacterial vaginosis, and leukocyte esterase were all independent risk factors for HR-HPV infection. Conclusion: There is age distribution characteristics in HR-HPV infection. The vaginal microenvironment and the increase of IL-4 level in vaginal lavage fluid are closely related to its classification.

Key words:

vaginal microenvironment">; vaginal flora">; interleukin-4">; high-risk human papilloma virus

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