Analysis of the Prognostic Roles of HIF-1α in Gastric Carcinoma Using Data Mining Technology

doi:10. 3969 / j. issn. 2096-2266. 2018. 02. 008

Abstract

Abstract: Objective: To analyze the prognostic roles of HIF-1α expression in gastric carcinoma based on data mining. Methods:
Using Oncomine database to analyze the expression of HIF-1α in gastric carcinoma. Using cBioportal online tool to analyze the gene
mutation of HIF-1α in gastric carcinoma. Using Kaplan-Meier Plotter database to analyze the prognostic roles of HIF-1α in gastric
carcinoma patients. Results: A total of 12 studies were involved HIF-1α in gastric carcinoma tissues and normal tissues, including 798
samples. Overall, using Kaplan Meier-Plotter database to analyze the prognostic roles of HIF- 1α in gastric carcinoma patients, the
results showed that high HIF-1α expression could improve the survival time of the patients with intestinal type gastric, with diffused
gastric carcinoma, or with mixed type gastric carcinoma, respectively（HR＜1.0, P＜0.05）. Conclusion: Through data mining, it is
suggested that HIF- 1α is highly expressed in gastric carcinoma tissue, and the prognosis of patients with gastric carcinoma was
strongly correlated with the HIF-1α expression. HIF-1α is the protective factor for the prognosis of gastric cancer.

Key words: HIF-1α, gastric cancer, data mining, prognosis

Sun Meitao, Zi Jiaji, Chen Ying, Yan Changbao, Dai Liping, Yu Min, Xiong Wei. Analysis of the Prognostic Roles of HIF-1α in Gastric Carcinoma Using Data Mining Technology[J]. Journal of Dali University, DOI: 10. 3969 / j. issn. 2096-2266. 2018. 02. 008.

References

〔1〕TORRE L A，BRAY F，SIEGEL R L，et al. Global cancer
statistics，2012〔J〕. CA Cancer J Clin，2015，65（2）：87-108.
〔2〕CREW K D，NEUGUT A I. Epidemiology of gastric can?
cer〔J〕. World J Gastroenterol，2006，12（3）：354-362.
〔3〕YANG L. Incidence and mortality of gastric cancer in Chi?
na〔J〕. World J Gastroenterol，2006，12（1）：17-20.
〔4〕韩毅力，程永毅，徐永刚. 低氧条件下HIF-1α对HGF表
达影响的观察〔J〕. 中华肿瘤防治杂志，2012，19（18）：
1377-1379.
〔5〕SEMENZA G L，WANG G L. A nuclear factor induced by
hypoxia via de novo protein synthesis binds to the human
erythropoietin gene enhancer at a site required for tran?
scriptional activation.〔J〕. Molecular and Cellular Biology，
1992，12（12）：5447-5454.
〔6〕LI L，ZHANG L，ZHANG X，et al. Hypoxia-inducible fac?
tor linked to differential kidney cancer risk seen with type
2A and type 2B VHL mutations〔J〕. Mol Cell Biol，2007，27
（15）：5381-5392.
〔7〕SEMENZA G L. Hypoxia-inducible factors in physiology
and medicine〔J〕. Cell，2012，148（3）：399-408.
〔8〕VAUPEL P，MAYER A. Hypoxia in cancer：significance
and impact on clinical outcome〔J〕. Cancer Metastasis Rev，
2007，26（2）：225-239.
〔9〕BROWN J M. The hypoxic cell：a target for selective cancer
therapy- eighteenth Bruce F. Cain Memorial Award lec?
ture〔J〕. Cancer Res，1999，59（23）：5863-5870.
〔10〕CHEN X，LEUNG S Y，YUEN S T，et al. Variation in gene
expression patterns in human gastric cancers〔J〕. Mol Biol
Cell，2003，14（8）：3208-3215.
〔11〕CHO J Y，LIM J Y，CHEONG J H，et al. Gene expression
signature- based prognostic risk score in gastric can?
cer〔J〕. Clin Cancer Res，2011，17（7）：1850-1857.
〔12〕CUI J，CHEN Y，CHOU W C，et al. An integrated tran?
scriptomic and computational analysis for biomarker iden?
tification in gastric cancer〔J〕. Nucleic Acids Research，
2011，39（4）：1197-1207.
〔13〕D'ERRICO M，DE RINALDIS E，BLASI M F，et al. Ge?
nome-wide expression profile of sporadic gastric cancers
with microsatellite instability〔J〕. Eur J Cancer，2009，45
（3）：461-469.
〔14〕WANG Q，WEN Y G，LI D P，et al. Upregulated INHBA
expression is associated with poor survival in gastric can?
cer〔J〕. Med Oncol，2012，29（1）：77-83.
〔15〕高燕，崔艳欣，姜相君. Dnmt1基因单核苷酸多态性与
胃癌的关系〔J〕. 中国癌症防治杂志，2015，7（6）：394-
397.
〔16〕CUNINGHAME S，JACKSON R，ZEHBE I. Hypoxia-in?
ducible factor 1 and its role in viral carcinogenesis〔J〕. Vi?
rology，2014（456/457）：370-383.
〔17〕窦鹏挥，胡春荣，马利峰，等. PTEN和缺氧诱导因子-
1α 在食管鳞癌组织中的表达〔J〕. 黑龙江医药科学，
2017，40（1）：67-68.
〔18〕SEMENZA G L. Targeting HIF-1 for cancer therapy〔J〕.
Nat Rev Cancer，2003，3（10）：721-732.
〔19〕王巍，张志常，宋晓雯，等. 基于数据挖掘分析PDCD5
表达对胃癌预后的影响〔J〕. 现代肿瘤医学，2016，24
（24）：3957-3959.
〔20〕黄震震. 基于整合的TCGA数据库探索基因组学与临
床数据关系〔D〕. 杭州：浙江大学，2016.
〔21〕SZÁSZ A M，LÁNCZKY A，NAGY Á，et al. Cross-valida?
tion of survival associated biomarkers in gastric cancer us?
ing transcriptomic data of 1，065 patients〔J〕. Oncotarget，
2016，7（31）：49322-49333.

[1]	Zhu Wenjuan¹, Gui Lingling¹, Ming Jing². Relationship of Psychological Stress with Empowerment and Coping Styles in Patients after Gastric#br# Cancer Surgery [J]. Journal of Dali University, 2026, 11(4): 28-34.
[2]	Yang Yanmeng, Wang Guangming, Cheng Yuhao, Zhang Juntao, Hu Zuhang, Tang Yanlong. Prediction of Prognosis in Ischemic Stroke Patients Using Dual-Source CT Perfusion Imaging Parameters [J]. Journal of Dali University, 2025, 10(4): 65-69.
[3]	Hong Xiao¹, Liao Shengkai¹, Zhou Jing², Li Jiancheng¹. Effects of Serum HGF, uPA, IL-17, and IL-24 on the Prognosis of Patients with Oral Squamous#br# Cell Carcinoma [J]. Journal of Dali University, 2025, 10(2): 60-66.
[4]	He Jintao, , Li Hanwei , Wang Xiaoyi, , Yang Yongqin , Zhang Yepin , Mei Wen , Xiong Wei, . Expression and Prognostic Significance of TRIM28 in Pleural Mesothelioma [J]. Journal of Dali University, 2025, 10(10): 30-38.
[5]	Yang Cuiying , Chen Yiming. Analysis of Gene DPT Expression in Gastric Cancer Patients [J]. Journal of Dali University, 2024, 9(10): 40-43.
[6]	Yao Qiuyan, Wu Zesheng, Shi Rognjie, Yang Liwei. Analysis of Short-Term Prognostic Factors in Alcoholic Liver Disease-Related Acute-on-Chronic Liver Failure [J]. Journal of Dali University, 2023, 8(2): 36-41.
[7]	Zhao Qinyi, Hei Shaomin . Weighted Co-Location Pattern Mining Method Based on Specified Features [J]. Journal of Dali University, 2023, 8(12): 15-21.
[8]	Li Chunyan. The Prognostic Value of NLR and PLR in Patients with Maintenance Hemodialysis [J]. Journal of Dali University, 2023, 8(10): 76-80.
[9]	Zeng Xin, Zhang Xiaoling, Li Xiaowei. An Effective Algorithm for Mining High Average-Utility Co-Location Patterns [J]. Journal of Dali University, 2022, 7(6): 9-17.
[10]	Li Bin, Li Sufen, Yang Na, Xiong Wei. Expression and Significance of THBS2 Gene mRNA in Human Malignant Pleural Mesothelioma Based on Tumor Databases [J]. Journal of Dali University, 2022, 7(4): 26-33.
[11]	Xiong Wei, Li Bin, Wang Boyong, Liu Ruai, Jiang Bei, Zi Jiaji, Zhou Jinghua. Research Progress on the Relationship between Lysyl Oxidase （LOX） Family Proteins and Gastric Cancer [J]. Journal of Dali University, 2022, 7(10): 75-80.
[12]	Zeng Xin, Li Zhenpeng, Yang Jian, Li Xiaowei. High Average-Utility Co-Location Patterns Mining Algorithm with Rare Features [J]. Journal of Dali University, 2021, 6(12): 5-11.
[13]	Wu Zeyu, Cen Jianchang, Li Zeqi, Xie Renhua, Gao Hong, Su Ping. A Case of Pregnancy-Induced Cerebral Venous Sinus Thrombosis and Literature Review [J]. Journal of Dali University, 2021, 6(10): 49-.
[14]	Shi Rongjie,Chen Xu,Cun Xiangnong . Clinical Analysis of 18 Cases with Obturator Hernia [J]. Journal of Dali University, 2020, 5(2): 65-67.
[15]	Huang Lihua, Luo Jiao, Li Quanrun, Gu Wei. Two Cases Report of HFRS Complicated with AP and Literature Review [J]. Journal of Dali University, 2020, 5(10): 48-50.