Journal of Dali University ›› 2022, Vol. 7 ›› Issue (8): 46-54.

Previous Articles     Next Articles

Research Progress on the Regulation Mechanism of Transcription of Mammalian Mitochondrial DNA

Xiong Wei1,2,3, Liu Ruai1,2,3, Li Bin1,2,3, Zhang Bensi1,2,3, Jiang Bei3, Yu Min4*   

  1. (1. Pre-clinical College,Dali University, Dali, Yunnan 671000, China; 2. Key Laboratory of Clinical Biochemistry of Yunnan Province, Dali, Yunnan 671000, China;3. Yunnan Key Laboratory of Screening and Research on Anti-Pathogenic Plant Resources from West Yunnan, Dali University, Yunnan 671000, China;4. College of Life Sciences, Yunnan University, Kunming 650091, China)

  • Received:2021-10-04 Revised:2021-10-13 Online:2022-08-15 Published:2022-09-16

Abstract:

Mitochondria are the principal site of ATP generation, and are involved in the regulation of apoptosis, calcium homeostasis, and innate immune response. The role of mitochondiral dysfunction in the occurrence and developmant of many huamn diseases has received increasing attention, which has promoted the biochemical study on the transcription process and regulation mechanism of mitochondria. The expression and regulation of the mitochondrial gene is very unique because it is regulated by both mitochondrial DNA (mtDNA) and nuclear genome. This essay reviews the research progress that has been done on the structure, transcriptional process and regulatory mechanism of mammalian mtDNA, and focuses on describing a variety of direct and indirect factors influencing mtDNA transcription. The hot issues relevant to its medical research will be analyzed and prospected.

Key words: mitochondrial DNA, regulation of transcription, mitochondrial transcription factor, hormone

CLC Number: