Abstract:

〔Abstract〕 Objective：To investigate the antioxidant and analgesic activities of the chemical components of Astragalus acaulis roots. Methods： The analgesic and antioxidant activities of samples isolated from A. acaulis roots were tested by acetic acid-induced writhing test， hot water tail-flick test and 1， 1-diphenyl-2- picrylhydrazyl （DPPH） free radical scavenging test. Results： The writhing inhibition rate of 5-methoxylarch-4-O-β-D-glucoside was 78.80% in acetic acid-induced writhing in mice， while the mean pain threshold increased by 1.84 seconds in the hot water tail-flick test after the mice were given syringaresinol-4-O-β-D-glucoside for 60 minutes compared with that before administration， indicating that the compound had significant peripheral analgesic activity. In DPPH free radical scavenging experiment， larch alcohol-4-O-β-D-glucoside and 5-methoxylarch-4-O-β-D-glucoside displayed good antioxidant activity with the average IC50 values of 38.40 μg/mL and 36.53 μg/mL， respectively. Conclusion： The lignans from the roots of A. acaulis have good antioxidant and peripheral analgesic activities. The study provides experimental basis for further understanding the bioactivity of the roots of Astragalus.

Key words:

"> font-size:10.5pt, ">Astragalus acaulis, roots, lignans, bioactivity