Correlation Analysis of UCP1 Gene -3826 A > G Locus Polymorphism and Body Mass Index in College Students

Abstract

Abstract:

〔Abstract〕 Objective： To explore the relationship between the UCP1 gene -3826 A>G locus polymorphism and body mass index （BMI） in college students. Methods： 308 college students were randomly selected， and the genomic DNA were extracted from exfoliated cells of oral mucosa. The height and body weight of the subjects were recorded. The polymorphism of UCP1 gene -3826 A >G locus was detected by KASP technology. The genotype frequencies， allele frequencies and the relationship between different genotypes and BMI were statistically analyzed. Results： Among the 308 subjects， including 96 cases（31.2%） were male and 212 cases（68.8%） were female， 64 cases （20.8%） were AA genotype （wild type）， 216 cases （70.1%） were AG genotype （heterozygous variant）， and 28 cases（9.1%） were GG genotype（homozygous variant）. There was no statistical significance in the composition ratio of genotypes between different genders. The mutation frequency of UCP1 gene -3836 A>G locus increased with the increase of BMI， and the difference was statistically significant （P<0.05）； the risk assessment showed that the GG genotype increased the risk of body weight increase by 3.875 times compared with the normal group. Conclusion： The results indicated that the UCP1 gene-3826 A>G locus polymorphism was associated with the BMI， the homozygous variant at this locus will increase the risk of body weight increase.

Key words:

"> font-size:10.5pt, ">uncoupling protein 1, gene polymorphism, genotype, body mass index

CLC Number:

Liu Yongxin, Chen Yan, Li Qiyan, Wang Yuqing, Lai Mingming .

Correlation Analysis of UCP1 Gene -3826 A > G Locus Polymorphism and Body Mass Index in College Students [J]. Journal of Dali University, 2022, 7(10): 47-51.

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