Optimization of Ｓelective Ester Hydrolysis
Conditions for Depresteroside

Abstract

Abstract: Objective： To efficiently obtain the compounds Secologanolyl-7-loganate（2）， Loganinic acid（3） and Demethyl-secologanol（4） from Depresteroside（1）， the hydrolysis conditions were investigated and optimized. Methods： The effects of alkali type and dosage， reaction temperature， reaction time and alkali concentration on the yield of hydrolyzed products 2， 3 and 4 of 1 were investigated by single factor method. Results： When 3.3 equivalent 0.10 mol/L Na2CO3 solution was heated at 45 ℃ for 12 hours， only compound 2 was produced， and the yield reached 87.2%. Compounds 3 and 4 can be completely synthesized by using 7.6 equivalent 0.10 mol/L NaOH solution at 45 ℃ for 13 hours with yields of 89.0% and 90.8%， respectively. Conclusion： The optimized hydrolysis conditions can obviously improve the yield of 2， 3 and 4.

Key words: font-family:Times New Roman, ">Depresterosidefont-family:Times New Roman, ">；font-family:Times New Roman, "> hydrolysis reactionfont-family:Times New Roman, ">；font-family:Times New Roman, "> Secologanolyl-7-loganatefont-family:Times New Roman, ">；font-family:Times New Roman, "> Loganic acidfont-family:Times New Roman, ">；font-family:Times New Roman, "> ">Demethylsecologanol

CLC Number:

Lai Yuxia, Guo Haihui, Qin Zikang, Shan Fang, Wang Fusheng.

Optimization of Ｓelective Ester Hydrolysis Conditions for Depresteroside [J]. Journal of Dali University, 2023, 8(8): 25-29.

References

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Optimization of Ｓelective Ester Hydrolysis Conditions for Depresteroside

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