Cell Proliferation Effect of Periplaneta americana Extracts on Hepatic Stellate Cells

J4 ›› 2012, Vol. 11 ›› Issue (6): 16-19.

Cell Proliferation Effect of Periplaneta americana Extracts on Hepatic Stellate Cells

Objective: To study the proliferation effects of Periplaneta americana extracts （samples I, II, III）on rat hepatic stellate cell lines （HSC-T6）in vitro. Methods: HSC-T6 proliferation under the treatment of Periplaneta americana extracts in different concentration and time was determined by MTT method. Results: Compared with the control group, HSC-T6 proliferation was inhibited by sample I with time dependence and reached the peak at 72 hours with concentration dependence within a certain range. Sample IIshowed the same inhibitory pattern but with less effect. Sample III showed a particular inhibition effect in 24 hours, and no effect at other time points. Conclusion: The samples I, II, III can inhibit hepatic stellate cell proliferation, which may be a potential drug for prevention and treatment of liver fibrosis.

College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China

Online:2012-06-15 Published:2012-06-15

Abstract

Abstract:

Key words: hepatic stellate cells, Periplaneta americana extracts, cell proliferation, inhibition

CLC Number:

R285.5

ZHANG Xiao-Xue, LI Chun-Yan, XU Jing, LEI Zhan-Ping, DUAN Yun-Zhong, LAI Yong. Cell Proliferation Effect of Periplaneta americana Extracts on Hepatic Stellate Cells[J]. J4, 2012, 11(6): 16-19.

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Cell Proliferation Effect of Periplaneta americana Extracts on Hepatic Stellate Cells

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