关键词: 羟乙基淀粉, 预扩容, 腰-硬联合麻醉, 剖宫产

Abstract:

Objective: To observe the clinical effects of hydroxyethyl starch preload undergoing combined spinal epidural anesthesia （CSEA）for cesarean section. Methods: Sixty cases of CSEA, scheduled for elective cesarean section, were randomly divided into two groups. The hydroxyethyl starch preload（HES）group（n=30）was given 6% hydroxyethyl starch 130/0.4 sodium chloride injection 500 mL  pre-expansion. The sodium lactate ringer's injection（LR）group（n=30）was given lactated ringer's injection 500 mL preexpansion.
The hypotension after anesthesia, nausea and vomiting and the amount of ephedrine and intraoperative fluid as well in two groups were recorded. Results: The incidence rates of hypotension after anesthesia, as well as the nausea and vomiting, the amount of ephedrine and the amount of intraoperative fluid in HES group were statistically lower than that in the LR group, respectively. Conclusion: Hydroxyethyl starch preload could better maintain the hemodynamic stability during the cesarean section than sodium lactate ringer, and it could safeguard the safety of maternal and fetal.

Key words: hydroxyethyl starch, preload, combined spinal epidural anesthesia, cesarean section