白血病G6PD蛋白表达的研究

J4 ›› 2011, Vol. 10 ›› Issue (2): 27-29.

白血病G6PD蛋白表达的研究

大理学院附属医院，云南大理 671000

收稿日期:2011-01-02 出版日期:2011-02-15 发布日期:2011-02-15
作者简介:蒋剑，2008级硕士研究生，主要从事血液病基础与临床研究.

Expression of G6PD Protein in Leukemia

Affiliated Hospital of Dali University, Dali, Yunnan 671000，China

Received:2011-01-02 Online:2011-02-15 Published:2011-02-15

摘要/Abstract

摘要：

目的：观察白血病患者骨髓中白血病细胞葡萄糖-6磷酸脱氢酶（G6PD）蛋白的表达情况，探讨G6PD与白血病的关系。方
法：应用免疫组化方法检测35例白血病患者和35例非恶性血液病患者骨髓组织标本中白血病细胞G6PD蛋白的表达，比较白血病患者和非恶性血液病患者G6PD蛋白表达率的差异。结果：G6PD蛋白在白血病骨髓组织白血病细胞中呈现弱阳性表达。35例白血病患者骨髓组织中G6PD蛋白阳性表达率为25.7% （9/35），而35例非恶性血液病患者骨髓组织中G6PD蛋白阳性表达率为2.9%（1/35），差异有统计学意义（P <0.05）。结论：白血病可能存在G6PD蛋白的表达上调，值得进一步研究。

关键词: G6PD蛋白, 白血病, 免疫组化

Abstract:

Objective: To investigate the expression of G6PD protein in human leukemia and analyze the relationship between G6PD and leukemia. Methods: Immunohistochemical method was applied to detect the expression of G6PD protein in the bone marrow tissue of 35 leukemia patients and 35 cases of non-hematologic malignancies. Non-hematologic malignancies were used as control group. The comparison of G6PD protein rate in leukemia patents and the control was studied. Results: The positive expression rate of G6PD protein was 25.7%（9/35）in leukemia patients and 2.9%（1/35）in control. Data showed a statistically significant difference in G6PD expression between the two groups （P <0.05）. Conclusion: G6PD protein was high expressed in leukemia, which needed further study.

Key words: G6PD protein, leukemia, immunohistochemistry

中图分类号:

R733.7

蒋剑, 李永萍, 潘云, 李正金, 王红霞. 白血病G6PD蛋白表达的研究[J]. J4, 2011, 10(2): 27-29.

JIANG Jian, LI Yong-Ping, PAN Yun, LI Zheng-Jin, WANG Hong-Xia. Expression of G6PD Protein in Leukemia[J]. J4, 2011, 10(2): 27-29.

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