J4 ›› 2012, Vol. 11 ›› Issue (6): 30-31.
目的：了解大理地区志贺菌的血清型分布及对12种常用抗生素的耐药性。方法：通过分离培养和鉴定得到68株志贺菌，血清学鉴定其血清型，K-B法检测其对12种抗生素的敏感性。结果：血清学鉴定显示68株志贺菌中福氏志贺菌41株，宋内氏志贺菌25株，鲍氏志贺菌2株。志贺菌对萘啶酸耐药率最高，对复方磺胺甲噁唑和氨苄西林耐药率较高；对头孢曲松和头孢噻肟较敏感，对喹诺酮类显示出不同程度的耐药。结论：大理地区以福氏志贺菌感染为主。在志贺菌治疗中可首选头孢曲松和头孢噻肟。
Objective: To investigate the serotype distribution of Shigellae in Dali and evaluate the resistance of Shigellae to 12 common used drugs. Methods: Serotypes of 68 isolated and identified strains of Shigellae were measured. K-B test was applied to define the drug-resistance of Shigellae to 12 different drugs. Results: Among 68 strains examined, 41 were Shigella Flexner, 25 were Shigella sonnei and 2 were Shigella boydii identified by serotype. Shigellae showed the highest drug resistance to nalidixic acid, with followed sulfalene and nalidixic and varying extents of drug resistance to quinolones; Shigellae was sensitive to ceftriaxone and cefotaxime. Conclusion: These results suggest that Shigella Flexner is the main infection strains in Dali and ceftriaxone and cefotaxime should be preferred in the treatment with Shigellae.
