关键词: 尿路感染, 大肠埃希菌, 超广谱茁-内酰胺酶, 细菌耐药性

Abstract:

Objective: To understand the distribution of causative organisms in urinary tract infection and drug resistance of
Escherichia coli in a hospital located in Baoshan in order to provide clinicians the basis for rational use of antibiotics. Methods:The identification of bacteria and susceptibility test were performed by using automatic bioanalysis- VITET-2 Compact 60 and Kirby-Bauer methods; the detection rate and the drug sensitivity results of bacterial were analyzed statistically. Results: The first three detection rates of causative bacteria in urine samples were: Escherichia coli topped （74.2%）, Klebsiella pneumoniae followed（10%）, Staphylococcus epidermidis was third （4.3%）. The detection rates of causative bacteria in the top three clinical departments were: department of urology 45.7%, department of rehabilitation 20%, ICU 14.3%. The top three drug resistance rates of 52 strains of Escherichia coli to 13 kinds of antibiotics were: ampicillin 98%, cotrimoxazole 76.9%, gentamicin 65.4%. All the strains of Escherichia coli were sensitive to ertapenem and imipenem; 29 cases of ESBL-producing Escherichia coli accounted for 55.8%, 23
cases of non ESBL-producing ones accounted for 44.2%. Conclusion: Escherichia coli are in the majority of urinary tract infections caused by organisms in hospital. The infectious cases in urinary department are first in the distribution of clinical departments. Since the drug resistance of Escherichia coli in urinary tract infection is serious, the hospital should strengthen monitoring of drug resistance of Escherichia coli and doctors should select antibiotics based on the results of drug sensitivity test in vitro.

Key words: urinary tract infection, Escherichia coli, ESBLS, drug resistance of bacteria