益肾活血平喘合剂对哮喘大鼠气道TGF β1表达的影响

J4 ›› 2013, Vol. 12 ›› Issue (6): 31-33.

益肾活血平喘合剂对哮喘大鼠气道TGF β₁表达的影响

1.中国中医科学院西苑医院，北京100091；2.大理学院附属医院，云南大理671000

收稿日期:2012-09-27 修回日期:2012-11-16 出版日期:2013-06-15 发布日期:2013-06-15
作者简介:张元元，高级讲师，主要从事临床医学教学研究.

Effects of YiShenHuoXue Decoction on TGF β₁ Expression in Asthma Rats

1. Xi Yuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China;
2. Affiliated Hospital of Dali University, Dali, Yunnan 671000, China

Received:2012-09-27 Revised:2012-11-16 Online:2013-06-15 Published:2013-06-15

摘要/Abstract

摘要：

目的：探讨益肾活血平喘合剂对哮喘大鼠气道TGF β₁表达的影响。方法：健康雌性SD大鼠60只。随机分为4组，即正常组、
模型组、地塞米松阳性对照组、益肾活血平喘合剂组，每组15只大鼠。除正常组外，其余3组均利用哮喘模型。各组于造模后14 d
开始每天给药及雾化吸入。造模后28 d处死动物，取同一部位肺叶，包埋，切片，HE染色及免疫组化检测气道TGF β₁的表达。结
果：益肾活血平喘合剂组气道TGF β₁的表达明显少于模型组（P<0.01）及阳性对照组（P<0.05）。结论：益肾活血平喘合剂通过抑
制气道TGF β₁的表达，减轻哮喘气道炎症及重塑的发生。

关键词: 益肾活血平喘合剂, 哮喘, TGF &beta, ₁

Abstract:

Objective: To investigate the effects of Yishenhuoxuepingchuan （YSHXPC）decoction on TGF β₁expression in airway
of asthma rats. Methods: Sixty health female SD rats were randomly divided into 4 groups （15 in each）: the normal group（normal
rats+saline）, the model group （athema rats+saline）, the positive control group （athema rats+hexadecadrol）, and the YSHXPC
decoction treatment group （athema rats+YSHXPV decoction）. Each group was delivered aerosol inhalation of drug every day since
the 14th day. Rats were sacrificed in the 28th day, pathological changes of lung observed by HE staining and TGF β₁ expression in
lung tissue by immunohistochemical stain were conducted. Results: The results showed that the TGF β₁ expression was higher in
normal group compared with other three groups. In YSHXPC decoction group, the TGF β₁ expression was reduced significantly
compared with the model group and the positive control group. Conclusion: This research showed that YSHXPC decoction can
effectively inhibit the TGF β₁ expression in experimental rats with asthma.

Key words: Yishenhuoxuepingchuan（YSHXPC）decoction, asthma, TGF β₁

中图分类号:

R256.12

张元元, 张燕萍, 王书臣, 林加杨, 樊茂蓉. 益肾活血平喘合剂对哮喘大鼠气道TGF β₁表达的影响[J]. J4, 2013, 12(6): 31-33.

ZHANG Yuan-Yuan, ZHANG Yan-Ping, WANG Shu-Chen, LIN Jia-Yang, FAN Mao-Rong. Effects of YiShenHuoXue Decoction on TGF β₁ Expression in Asthma Rats[J]. J4, 2013, 12(6): 31-33.

益肾活血平喘合剂对哮喘大鼠气道TGF β₁表达的影响

Effects of YiShenHuoXue Decoction on TGF β₁ Expression in Asthma Rats

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