关键词: 细菌耐药性监测, 抗生素, 药敏试验, 耐药率

Abstract:

Objective: To investigate the resistance of clinical isolates in the Chinese Medicine Hospital of Chuxiong Prefecture in
2011. Methods: Antimicrobial susceptibility testing of 946 clinical isolates were carried out by Kirby-Bauer （K-B）method and microdilution method. Results: Among the 1 127 clinical isolates, gram-negative bacteria and gram-positive bacteria accounted for 76.8% and 23.2%, respectively. In 865 gram negative bacillis, E. coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. accounted for 45.7% （395/865）, 10.6%（92/865）and 9.0%（78/865）, respectively. In 262 gram positive cocci, E. faecium,S. aureus and Staphylococcus epidermidis. accounted for 27.1% （71/262）, 24.8% （65/262）and 16.0%（42/262）. Susceptibility test results showed that Pseudomonas aeruginosa and Acinetobacter spp. were detected in 19.2% （15/78）and 32.8% （23/70）pan-resistant strains. The prevalence of emethicillin-resistant Staphylococcus was 83.3% （40/48）in S. aureus and 32.3% （21/65）incoagulasenegative Staphylococcus. Conclusion: Surveillance of bacterial resistance is most important and valuable for guidance of rational selection of antimicrobial agents.

Key words: bacterial resistance surveillance, antimicrobial agents, susceptibility testing, resistance rate