天南星提取物的抗炎作用及机制研究

J4 ›› 2013, Vol. 12 ›› Issue (9): 14-16.

天南星提取物的抗炎作用及机制研究

1.大理学院，云南大理 671003；2.大理学院药学与化学学院，云南大理 671000

收稿日期:2013-08-29 修回日期:2013-09-03 出版日期:2013-09-15 发布日期:2013-09-15
作者简介:李杨，助理编辑，主要从事药物分析及活性研究.
基金资助:
云南省教育厅研究生基金资助项目（2011J057）

Study on Anti-inflammatory Effect and Mechanism of the Extract in Arisaemaerubescens

1.Dali University, Dali, Yunnan 671003, China；2. College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China

Received:2013-08-29 Revised:2013-09-03 Online:2013-09-15 Published:2013-09-15

摘要/Abstract

摘要：

目的：观察天南星提取物的抗炎作用并分析其机制。方法：采用二甲苯致小鼠耳廓肿胀、棉球诱发小鼠肉芽肿增生及醋
酸致小鼠腹腔毛细血管通透性增加等三种模型，观察天南星提取物对不同炎症模型的抗炎作用。结果：天南星块茎醇提取物、乙酸乙酯提取物，天南星果实石油醚提取物均能明显抑制二甲苯致小鼠耳廓肿胀度（P<0.01）；能减轻小鼠棉球肉芽肿（P<0.01）；且能明显降低小鼠毛细血管通透性（P<0.01，P<0.05）。结论：天南星上述提取物具有明显的抗炎作用，其抗炎作用可能与降低血管通透性有关。本实验为其开发利用提供了科学的依据。

关键词: 天南星提取物, 抗炎作用, 药效试验

Abstract:

Objective:To observe the anti -inflammatory effectsofthe extract in Arisaemaerubescens and explore the underlying
mechanism. Methods: Mice auricle edemawasinduced by dimethylbenzene, mice abdominal cavity capillary permeability was increased by acetic acid, and thegranuloma was induced by cotton pellet. The anti-inflammatory effectof the extract in differentmodels was observed. Results: Ethanol extract,ethyl acetate extract of Arisaemaerubescens （Wall.）Schott tuber and Petroleum ether extract of Arisaemaerubescens（Wall.）Schottfruit showed significant inhibitory action on auricle edema induced by dimethylbenzene in mice （P<0.01）and on penetration of capillary vessel in mice （P<0.01 or P<0.05）, andsignificantly decreased the proliferation of
granuloma caused by implantation cotton pellet in mice （P<0.01）Conclusion:Extract in Arisaemaerubescenshas significantantiinflammation action, which would be related to the decreased capillary permeability. The researches provided a scientific basis for the developing and utilizing of Arisaemaerubescens.

Key words: extract of Arisaemaerubescens, anti-inflammatory effect, pharmacokinetics

中图分类号:

R285.5

李杨, 陆倩, 钱金栿. 天南星提取物的抗炎作用及机制研究[J]. J4, 2013, 12(9): 14-16.

LI Yang, LU Qian, QIAN Jin-Fu. Study on Anti-inflammatory Effect and Mechanism of the Extract in Arisaemaerubescens[J]. J4, 2013, 12(9): 14-16.

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