基于NetMatchStar的miRNA-mRNA调控网络研究

›› 2017, Vol. 2 ›› Issue (12): 44-48.

基于NetMatchStar的miRNA-mRNA调控网络研究

（1.大理大学工程学院，云南大理671003；2.大理大学农学与生物科学学院，云南大理671003）

收稿日期:2017-10-25 出版日期:2017-12-15 发布日期:2017-12-15
作者简介:张俊鹏，副教授，主要从事生物信息学研究.
基金资助:
云南省应用基础研究计划项目（2017FB099）

Research in miRNA-mRNA Regulatory Network Based on NetMatchStar

（1.College of Engineering, Dali University, Dali, Yunnan 671003, China; 2. College of Agriculture and Biology Science, Dali University, Dali, Yunnan 671003, China）

Received:2017-10-25 Online:2017-12-15 Published:2017-12-15

摘要/Abstract

摘要： 为了研究微小RNA与信使RNA之间的调控关系，基于网络匹配方法对miRTarBase、TarBase和miRWalk 3种数据库组成的整合型miRNA-mRNA调控网络进行网络模体挖掘，然后对其构成的子网络进行靶基因信号通道富集分析。实验结果表明：miRNA-mRNA调控子网络简化了基因调控网络分析，并且通过靶基因富集分析有助于了解miRNA的生物学功能。

关键词: 微小RNA, 信使RNA, miRNA-mRNA调控网络, NetMatchStar, 网络模体, 富集分析

Abstract: To study the regulatory relationships between miRNAs and mRNAs, the network match star（NetMatchStar）method is applied to identify network motifs of the integrated miRNA-mRNA regulatory network, including miRTarBase, TarBase, and miRWalk databases. Then, this study performs a pathway enrichment analysis of the target genes in the sub- networks constituted by the identified network motifs. Results show that the miRNA-mRNA regulatory sub-networks could simplify the analysis of gene regulatory networks. Moreover, the enrichment analysis of target genes could help understand the biological functions of miRNAs.

Key words: miRNA, mRNA, miRNA-mRNA regulatory network, NetMatchStar, network motif, enrichment analysis

中图分类号:

R318.04

张俊鹏，张武. 基于NetMatchStar的miRNA-mRNA调控网络研究[J]. , 2017, 2(12): 44-48.

Zhang Junpeng, Zhang Wu. Research in miRNA-mRNA Regulatory Network Based on NetMatchStar[J]. , 2017, 2(12): 44-48.

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