关键词: 扶正辟邪颗粒, 挥发油, β-环糊精, 提取工艺, 包合工艺

Abstract: Objective: To optimize the extraction and inclusion process of volatile oil from Fuzheng Pixie granules. Methods: L9（34）
orthogonal design experiment was used to optimize the extraction process of volatile oil, with the oil yield as the index. The inclusion
process of volatile oil with β-cyclodextrin was optimized with the yield of inclusion complex and the inclusion rate of volatile oil as the
indexes. Results: The optimal extraction process of volatile oil was soaking in 10 times the amount of water for 0.5 hours, followed by
extraction for 4.5 hours. The average oil yield of volatile oil in three verification tests was （0.91±0.01）%. The optimal inclusion process
of volatile oil was a ratio of β-cyclodextrin to volatile oil of 10：1, inclusion temperature of 40 ℃, and inclusion time of 3 hours. The
average yield of inclusion complex in three verification tests was （84.48±0.75）%, and the average inclusion rate of volatile oil was
（90.69±0.79）% . Conclusion: The optimal extraction process and the optimal inclusion process of volatile oil of Fuzheng Pixie
granules are reasonable in design and stable in results, which are suitable for industrial production.

Key words: Fuzheng Pixie granules, volatile oil, β-cyclodextrin, extraction process, inclusion process