关键词: 妊娠期, 亚临床性甲状腺功能减退症, 左甲状腺素, 音乐疗法, 焦虑, 抑郁

Abstract: Objective: To investigate the clinical efficacy of levothyroxine combined with music therapy in the treatment of
subclinical hypothyroidism （SCH） in pregnant women. Methods: A total of 100 pregnant women diagnosed with SCH, admitted to the
department of obstetrics at Xiangcheng People's Hospital in Suzhou from December 2022 to March 2023, were divided into the control
group （treated with levothyroxine alone） and the experimental group （treated with levothyroxine combined with music therapy） using
the random number table method. Thyroid function indicators, lipid metabolism indicators, homocysteine （Hcy） and folic acid levels,
anxiety, depression, and pregnancy complications were compared between the two groups before and after treatment. Results: The serum
thyroid stimulating hormone contents in both groups significantly decreased after treatment（P<0.01）, but the intergroup differences were
not statistically significant（ P>0.05）. There were no statistically significant differences in lipid metabolism indicators, Hcy, and folic acid
levels between the two groups（ P>0.05）. The anxiety and depression scores in the experimental group improved significantly compared to
the control group, and the incidence of pregnancy complications in the experimental group was significantly lower than that in the control
group （P<0.05）. Conclusion: Levothyroxine combined with music therapy can effectively improve anxiety and depression in pregnant
women with SCH, reduce the occurrence of pregnancy complications, and is worthy of further clinical promotion and application.

Key words: pregnancy, subclinical hypothyroidism, levothyroxine, music therapy, anxiety, depression