维持血透患者血清iPTH及PTH（1-84）的临床研究

J4 ›› 2016, Vol. 15 ›› Issue (2): 45-47.

维持血透患者血清iPTH及PTH（1-84）的临床研究

（大理大学附属医院，云南大理671000）

收稿日期:2015-07-29 出版日期:2016-02-15 发布日期:2016-02-15
作者简介:刘进，主治医师，主要从事临床核医学研究.

Clinical Study of Serum iPTH and PTH（1-84）in Maintained Hemodialysis Patients

（Affiliated Hospital of Dali University, Dali, Yunnan 671000, China）

Received:2015-07-29 Online:2016-02-15 Published:2016-02-15

摘要/Abstract

摘要：

目的：通过对维持血液透析患者血清全段甲状旁腺激素（iPTH）及生物活性全段甲状旁腺激素（PTH1-84）浓度的测定，
比较和评价其对维持血透患者血清甲状旁腺激素监测的意义。方法：选择大理大学附属医院32例维持血液透析患者，健康对
照组30 例，采用Elecsy e2010 全自动电化学发光分析仪及配套试剂检测血清iPTH 及PTH（1-84）的浓度。所有数据采用
SPSS13.0分析软件进行统计分析。结果：维持血透组患者血清iPTH、PTH（1-84）均高于对照组，差异有统计学意义（P<0.01），透析组iPTH高于PTH（1-84），差异有统计学意义（P<0.05），二者呈显著正相关（r=0.927 7，P<0.01），正常对照组血清iPTH、PTH（1-84）比较，差异无统计学意义（P>0.05）。结论：维持血透患者iPTH、PTH（1-84）均明显升高，二者呈显著正相关，PTH（1-84）对维持血透患者血清甲状旁腺激素监测价值优于iPTH。

关键词: 维持血液透析, 全段甲状旁腺激素（iPTH）, 生物活性全段甲状旁腺激素（PTH1-84）

Abstract:

Objective: To compare and evaluate the significance of monitoring maintained hemodialysis（MHD）patient's serum intact
parathyroid hormone through the detection of MHD patient's serum intact parathyroid hormone（iPTH）and the concentration of biological activity intact parathyroid hormone l-84（PTH 1-84）. Methods: 32 MHD patients from Affiliated Hospital of Dali University were enrolled in this study, the control group included 30 healthy people. The concentrations of serum iPTH and PTH（1-84）were detected by Cobas e2010 automatic chemiluminescence analyzer. And all data was analyzed by SPSS13.0 software for statistical analysis. Results: The serum levels of iPTH and PTH（1-84）were higher in the maintained hemodialysis group than in the control group, difference was statistically significant（P<0.01）, the iPTH of the dialysis group was higher than that of PTH（1-84）, and the difference was statistically significant（P<0.05）, in MHD patients，the serum iPTH and PTH（1-84）showed a significant correlation respectively（r=0.927 7，P<0.01）, there was no significant difference between normal control group iPTH and PTH（1-84）（P>0.05）.Conclusion: In MHD patients, the concentrations of serum iPTH and 1-84（PTH）were significantly higher and there was a positive correlation between them, so the value of PTH（1-84）diagnosis of renal osteodystrophy is better than iPTH.

Key words: maintenance hemodialysis, intact parathyroid hormone（iPTH）, biological activity intact parathyroid hormone l-84

中图分类号:

R459.5

刘进，肖榆辉，韩宏，邓天丽，谭旭辉. 维持血透患者血清iPTH及PTH（1-84）的临床研究[J]. J4, 2016, 15(2): 45-47.

Liu Jin, Xiao Yuhui, Han Hong, Deng Tianli, Tang Xuhui. Clinical Study of Serum iPTH and PTH（1-84）in Maintained Hemodialysis Patients[J]. J4, 2016, 15(2): 45-47.

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