215株肠球菌的临床分布与耐药性分析

J4 ›› 2016, Vol. 15 ›› Issue (2): 48-51.

215株肠球菌的临床分布与耐药性分析

（大理大学临床医学院，云南大理671000）

收稿日期:2015-10-28 出版日期:2016-02-15 发布日期:2016-02-15
作者简介:宋丹丹，硕士研究生，主要从事临床检验诊断、微生物研究.
基金资助:
云南省科技厅科研基金资助项目（2010ZC146）

Clinical Distribution and Drug Resistence of 215 Strains of Enterococcus

（Clinical College, Dali University, Dali, Yunnan 671000, China）

Received:2015-10-28 Online:2016-02-15 Published:2016-02-15

摘要/Abstract

摘要：

目的：了解近两年我院肠球菌的临床感染特点及其耐药情况，为临床用药提供更好的依据。方法：采用VITEK 2 Com?
pact全自动微生物分析仪做细菌鉴定和药敏试验，K-B纸片法做药敏试验及数据统计分析。结果：共检出粪肠球菌78株和屎
肠球菌116株，主要来自于尿液、分泌物、口痰。屎肠球菌的整体耐药率明显高于粪肠球菌。在受试抗生素中，肠球菌对替加环素的耐药率最低，均为0，其次为利奈唑胺和万古霉素。结论：临床上肠球菌感染以屎肠球菌、粪肠球菌为主。屎肠球菌对大多数抗生素耐药率高于粪肠球菌；替加环素、利奈唑胺、万古霉素是对肠球菌敏感率最高的抗生素，但已经出现耐万古霉素和耐利奈唑胺的肠球菌。因此临床应加强对肠球菌的检测，以减少耐药菌株的产生。

关键词: 肠球菌, 临床感染, 抗菌药物, 耐药性

Abstract:

Objective: To understand the clinical infection and drug resistance of enterococcal patients in our hospital in recent two
years and provide a better basis for clinical medication. Methods: VITEK 2 Compact was used for bacterial identification and drug sensitivity test, K-B method for drug sensitivity test and data analysis. Results: 116 strains of Enterococcus faecium and 78 strains of Enterococcus faecalis from the urine, secretions and sputum were detected. The overall resistance rate in Enterococcus faecium was significantly higher than that in the Enterococcus faecalis. In the subjects of antimicrobial agents, the drug resistence rate of Enterococcus to tigecycline was zero, followed by linezolid and vancomycin. Conclusion: Clinically, the main infections of Enterococcus were the feces and the fecal. The drug resistance rate of Enterococcus faecium to most of the antibiotics was higher than that of the Enterococcus faecalis. Tigecycline, linezolid and vancomycin were the most sensitive antibactarials to Enterococcus, but there has been Enterococcus resistant to vancomycin and linezolid. The clinical detection of Enterococcus should be strenghtened to reduce the generation of drug-resistant strains.

Key words: Enterococcus, clinical infection, antibiotics, drug resistance

中图分类号:

R446.5

宋丹丹，张群智. 215株肠球菌的临床分布与耐药性分析[J]. J4, 2016, 15(2): 48-51.

Song Dandan, Zhang Qunzhi. Clinical Distribution and Drug Resistence of 215 Strains of Enterococcus[J]. J4, 2016, 15(2): 48-51.

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