98株肺炎链球菌的临床分布及耐药性分析

J4 ›› 2016, Vol. 1 ›› Issue (8): 62-64.

98株肺炎链球菌的临床分布及耐药性分析

（1.大理大学临床医学院，云南大理671000；2. 大理大学附属医院，云南大理671000）

收稿日期:2015-07-15 修回日期:2015-10-30 出版日期:2016-08-15 发布日期:2016-08-15
作者简介:孔山，讲师，主要从事临床病原微生物研究.
基金资助:
云南省科技厅应用基础研究基金资助项目（2013FD095）

Analysis of the Clinical Distribution and Antibiotic Resistance of 98 Strains of Streptococcus Pneumoniae

（1. Clinical College, Dali University, Dali, Yunnan 671000, China; 2. Dali Affiliated Hospital of Dali University,
Dali, Yunnan 671000, China）

Received:2015-07-15 Revised:2015-10-30 Online:2016-08-15 Published:2016-08-15

摘要/Abstract

摘要：

目的：分析大理大学附属医院肺炎链球菌的临床分离情况及耐药性，为临床诊断和治疗提供参考和依据。方法：收集
2011年3月至2014 年3月分离的98株肺炎链球菌，菌株鉴定和药敏试验采用法国生物梅里埃VITEK-2 Compact全自动微生
物鉴定与药敏分析仪，药敏结果判读采用美国临床实验室标准协会（CLSI）2012版，耐药性分析采用WHONET5.6软件。结果：
98株肺炎链球菌中，分离自痰液77株、咽拭子15株、血液3株、脑脊液2株；科室来源以儿科、呼吸内科、ICU、皮肤科为主，分别
为34株、27株、16株和11株；年龄分布≤5岁儿童52株，≥60岁老年人34株。该菌对红霉素、四环素和复方新诺明的耐药率较
高，分别为90.8%、81.6%和80.6%，对青霉素的耐药率为26.5%，对头孢噻肟、厄他培南、阿莫西林、美罗培南和头孢曲松的耐药
率较低，均小于20%，未发现耐万古霉素、莫西沙星和利奈唑胺菌株。结论：肺炎链球菌感染以呼吸系统感染为主，感染人群以
儿童和老年人为主。临床应合理使用抗生素，防止耐药菌的不断增加。

关键词: 肺炎链球菌, 临床分布, 耐药性

Abstract:

Objective: To investigate the clinical distribution and antibiotic resistance of Streptococcus pneumoniae in the Affiliated
Hospital of Dali University in order to provide reference for clinical diagnosis and treatment. Methods: A total of 98 S. pneumoniae
were obtained from March 2011 to March 2014. The identification and drug sensitive test of all strains were measured by VITEK-2
Compact analyzer. Drug sensitivity results were interpreted by using the American Clinical and Laboratory Standards Institute（CLSI）
2012 Edition. The resistance results were analyzed via WHONET 5.6 software. Results: Among 98 strains of S. pneumoniae, 77 strains
were isolated from sputum, 15 from pharynx swab, 3 from blood and 2 from cerebrospinal fluid. Those strains were mainly from
Paediatrics, Respiratory Medicine, ICU, and Dermatology, respectively 34, 27, 16, and 11. 52 of the strains were from children of 5 and
under, and 34 were from the elderly people of 60 or over. The assay showed that the resistance rates of S. Pneumoniae to erythromycin,
tetracycline and SMZ-TMZ were relatively high, reaching 90.8%, 81.6% and 80.6% respectively. The resistance rateto penicillin was
26.5%. The resistance rates to cefotaxime, ertapenem, amoxicillin, meropenem and ceftriaxone were less than 20%. No vancomycin and
moxifloxacin and linezolidresistant strain was found. Conclusion：S. pneumoniae infection were mainly caused by respiratory infection.
S. pneumoniae infection was the commonest in children and the elderly. We should use antibiotics rationally so as to prevent the
increase of drug-resistant bacteria.

Key words: Streptococcus pneumoniae, clinical distribution, antibiotic resistance

中图分类号:

R446.5

孔山，忽胜和，杨新原，赵卫东. 98株肺炎链球菌的临床分布及耐药性分析[J]. J4, 2016, 1(8): 62-64.

Kong Shan, Hu Shenghe, Yang Xinyuan, Zhao Weidong. Analysis of the Clinical Distribution and Antibiotic Resistance of 98 Strains of Streptococcus Pneumoniae[J]. J4, 2016, 1(8): 62-64.

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