大理大学学报

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紫地榆中4种单体对3种致龋菌培养液中大分子物质吸光值的影响

  

  1. (大理大学药学与化学学院,云南大理671000)
  • 收稿日期:2017-07-01 出版日期:2018-02-15 发布日期:2018-02-15
  • 作者简介:李梦琪,硕士研究生,主要从事药物分析研究.
  • 基金资助:
    国家自然科学基金资助项目(81260512)

Absorption Value of Macromolecular Substances in Liquid Culture Medium Effected by Four Monomer#br# in Geranium Strictipes on Three Kinds of Cariogenic Bacteria

  1. (College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China)
  • Received:2017-07-01 Online:2018-02-15 Published:2018-02-15

摘要: 目的:研究紫地榆中4种单体对3种致龋菌培养液中大分子物质吸光值的影响。方法:以变形链球菌、黏性放线菌、嗜
酸乳杆菌为供试菌,测定不同浓度含药培养液对3种致龋菌培养液中大分子物质吸光值的影响。结果:没食子酸、没食子酸甲
酯、儿茶素、鞣花酸4种单体对3种致龋菌培养液中大分子物质的外漏有增强作用。并且随时间和药物浓度的增加,大分子物
质的吸光值逐渐增大。在2~8 h内,增长速度更明显,与阳性对照组相比,大多数组的效果优于阳性对照组。结论:紫地榆中4
种单体能增加致龋菌培养液中大分子物质的吸光值,能破坏细菌细胞膜的完整性。

关键词: 紫地榆, 致龋菌, 吸光值, 单体

Abstract: Objective: To study absorption value of macromolecular substances in liquid culture medium of four monomer in
Geranium strictipes on three kinds of cariogenic bacteria. Methods: The Streptococcus mutans, Actinomyces viscosus, Lactobacillus
acidophilus were tested as microbe to determinate absorption value of macromolecular substances in liquid culture medium of the four
monomer in Geranium strictipes on three kinds of cariogenic bacterias with different concentrations. Results: The Gallic acid, the
Methyl ester of Gallic acid, catechins, ellagic acid have an enhanced role to external leakage of macromolecular substances in liquid
culture medium to three kinds of cariogenic bacteria. With the time and drug concentration, the absorption value of substances in liquid
culture medium increases gradually, the growth rate was more obvious in 2~8 h, and the effect of most groups was better than that of the
positive control group. Conclusion: Four Monomers in Geranium strictipes have an enhanced role to external leakage of
macromolecular substances in liquid culture medium, which can destroy the integrity of bacterial cell membranes.

Key words: Geranium strictipes, cariogenic bacteria, absorption value, monomer