高海拔地区红细胞计数与高血压的相关性研究

doi:10. 3969 / j. issn. 2096-2266. 2021. 08. 012

大理大学学报 ›› 2021, Vol. 6 ›› Issue (8): 54-57.DOI: 10. 3969 / j. issn. 2096-2266. 2021. 08. 012

高海拔地区红细胞计数与高血压的相关性研究

胡乃青，吕晋琳，尹雪艳，李利华*

（大理大学第一附属医院老年病科，云南大理 671000）

收稿日期:2020-05-06 修回日期:2020-05-19 出版日期:2021-08-15 发布日期:2021-09-29
通讯作者: 李利华，教授，博士，E-mail：lilihuayncn@163.com。
作者简介:胡乃青，住院医师，主要从事高血压流行病学研究。
基金资助:
国家自然科学基金项目（81660072；81860084）；云南省中青年学术和技术带头人培养项目（2015HB056）；云
南省医学学科带头人培养项目（D-201672）；大理大学高血压防治创新团队项目（ZKPY2019304）；云南省万
人计划青年拔尖人才项目（云人社发〔2018〕73 号）

Study on the Correlation between Red Blood Cell Count and Hypertension at High Altitude

Hu Naiqing, Lü Jinlin, Yin Xueyan, Li Lihua*

(Department of Gerontology, The First Affiliated Hospital of Dali University, Dali, Yunnan 671000, China)

Received:2020-05-06 Revised:2020-05-19 Online:2021-08-15 Published:2021-09-29

摘要/Abstract

摘要： 目的：研究高海拔地区红细胞计数与血压水平和高血压患病的关系。方法：邀请大理市某工厂所有在职及退休职工参
与该研究，采用标准化问卷收集参与者的人口学信息、病史、吸烟、饮酒、高血压家族史等信息。采用SPSS 19.0 软件对数据
进行多元线性回归分析和Logistic 回归分析。结果：1 395 例参与者包括546 例女性（39.1%），460 例高血压患者（33.0%）。
多元线性回归分析发现，调整协变量后，红细胞计数与收缩压、舒张压正相关，血红蛋白与舒张压正相关。Logistic 回归分析发现，
调整协变量后，红细胞计数与高血压患病风险独立相关，红细胞计数每增加1 × 1012 个/L，高血压的患病风险增加92%（OR=1.920，
95%CI 1.161~3.175，P = 0.011），而血红蛋白与高血压患病风险无关（P = 0.361）。结论：高海拔地区红细胞计数与血压水平及
高血压患病风险正相关。高海拔地区长期慢性缺氧可能通过刺激红细胞增多参与血压的调节和高血压的发病。

关键词: 血压, 高血压, 红细胞计数, 血红蛋白, 高海拔地区

Abstract: Objective: To study the correlation between red blood cell count and blood pressure and hypertension at high altitude.
Methods: All employees and retired workers in a factory in Dali were invited to participate in this study, and a standardized
questionnaire was used to collect the participants’ demographic information, disease history, smoking and drinking habits, family
history of hypertension and so on. SPSS 19.0 was used for multiple linear regression analysis and Logistic regression analysis.
Results: The 1 395 participants included 546 women (39.1%) and 460 hypertensive patients (33.0%). Multiple linear regression
analysis showed that after adjusting for covariates, red blood cell count was positively correlated with systolic and diastolic blood
pressure, and hemoglobin level was positively correlated with diastolic blood pressure. Logistic regression analysis found that after
adjusting for covariates, red blood cell count was independently associated with the increased risk of hypertension. For each 1×1012/L
increase in red blood cell count, the risk of hypertension increased by 92% (OR=1.920, 95%CI 1.161-3.175, P=0.011), while
hemoglobin was not associated with the risk of hypertension (P= 0.361). Conclusion: Red blood cell count was positively correlated
with blood pressure and risk of hypertension at high altitude. Long-term chronic hypoxia at high altitude may be involved in the
regulation of blood pressure and the pathogenesis of hypertension by stimulating erythrocytosis.

Key words: blood pressure, hypertension, red blood cell count, hemoglobin, high altitude

中图分类号:

R749

胡乃青, 吕晋琳, 尹雪艳, 李利华. 高海拔地区红细胞计数与高血压的相关性研究[J]. 大理大学学报, 2021, 6(8): 54-57.

Hu Naiqing, Lü Jinlin, Yin Xueyan, Li Lihua. Study on the Correlation between Red Blood Cell Count and Hypertension at High Altitude[J]. Journal of Dali University, 2021, 6(8): 54-57.

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高海拔地区红细胞计数与高血压的相关性研究

Study on the Correlation between Red Blood Cell Count and Hypertension at High Altitude

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