NLR 在社区获得性肺炎病原诊断中的应用价值

doi:10. 3969 / j. issn. 2096-2266. 2021. 08. 021

大理大学学报 ›› 2021, Vol. 6 ›› Issue (8): 88-92.DOI: 10. 3969 / j. issn. 2096-2266. 2021. 08. 021

NLR 在社区获得性肺炎病原诊断中的应用价值

李福兴，和迎春，严萍，王黎，樊玉娟，赵卫东*

（大理大学临床医学院，云南大理 671000）

收稿日期:2020-10-22 修回日期:2020-12-15 出版日期:2021-08-15 发布日期:2021-09-29
通讯作者: 赵卫东，副教授，博士，E-mail：wdzhao@dali.edu.cn。
作者简介:李福兴，硕士研究生，主要从事临床微生物感染与免疫研究。
基金资助:
国家自然科学基金项目（81960363；82160361）；云南省教育厅科学研究基金项目（2021Y429）；云南省高层次
卫生计生技术人才培养经费资助项目（H-2019045）；云南省地方本科高校（部分）基础研究联合专项资金
项目（202001BA070001-040）

Clinical Application Value of NLR in the Etiology Diagnosis of Community-Acquired Pneumonia

Li Fuxing, He Yingchun, Yan Ping, Wang Li, Fan Yujuan, Zhao Weidong*

(Clinical College, Dali University, Dali, Yunnan 671000, China)

Received:2020-10-22 Revised:2020-12-15 Online:2021-08-15 Published:2021-09-29

摘要/Abstract

摘要： 目的：探讨中性粒细胞- 淋巴细胞比值（NLR）在社区获得性肺炎病原诊断中的临床应用价值。方法：回顾性分析47
例肺炎链球菌引起的细菌性肺炎（SP）、50 例支原体肺炎（MP）和64 例病毒性肺炎（VP）患者入院48 h 内的血常规、降钙
素原（PCT）和C反应蛋白（CRP）水平，选取NLR<5 作为截断值，并对检测结果进行统计分析。结果：SP 组患者白细胞（WBC）、
NLR、NLR<5、PCT 水平均显著高于MP 组和VP 组，差异均有统计学意义（P < 0.05）。在区分SP 与MP、SP 与VP、SP 与
非SP 时，NLR<5 的诊断效能均最佳，曲线下面积分别为0.92、0.74 和0.84。结论：NLR 可早期区分细菌性与非细菌性感染，
尤其当NLR<5 时，应考虑支原体或病毒等非细菌性感染，更好地指导临床用药。

关键词: 社区获得性肺炎, 中性粒细胞- 淋巴细胞比值, C反应蛋白, 降钙素原

Abstract: Objective: To explore the clinical application value of neutrophil-lymphocyte ratio (NLR) in the etiological diagnosis
of community-acquired pneumonia. Methods: The routine blood indices, CRP and the concentration of PCT were retrospectively
analyzed in 47 patients with streptococcus pneumonia (SP), 50 patients with mycoplasma pneumonia (MP) and 64 patients with viral
pneumonia (VP) within 48 hours after admission to hospital. NLR <5 was selected as cut-off value, and the results were analyzed by
statistical methods. Results: Compared with those in MP group and VP group, the patients in SP group had higher levers of white
blood cell counts, NLR, NLR<5, and PCT, the differences were statistically significant (P<0.05). NLR<5 had the best diagnostic
efficacy in distinguishing between SP and MP (AUC=0.92), VP (AUC=0.74), and non-SP (AUC=0.84), respectively. Conclusion:
NLR can distinguish bacterial infection from non-bacterial infection in the early stages. At the level of NLR<5, non-bacterial infection
such as mycoplasma or virus should be considered, which can better guide clinical medication.

Key words: community-acquired pneumonia, neutrophil-lymphocyte ratio, C-reactive protein, procalcitonin

中图分类号:

R563.1

李福兴, 和迎春, 严萍, 王黎, 樊玉娟, 赵卫东. NLR 在社区获得性肺炎病原诊断中的应用价值[J]. 大理大学学报, 2021, 6(8): 88-92.

Li Fuxing, He Yingchun, Yan Ping, Wang Li, Fan Yujuan, Zhao Weidong. Clinical Application Value of NLR in the Etiology Diagnosis of Community-Acquired Pneumonia[J]. Journal of Dali University, 2021, 6(8): 88-92.

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NLR 在社区获得性肺炎病原诊断中的应用价值

Clinical Application Value of NLR in the Etiology Diagnosis of Community-Acquired Pneumonia

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