大理大学学报 ›› 2023, Vol. 8 ›› Issue (8): 1-5.

• 药学 •    下一篇

绒毛灯笼花块根化学成分研究

李 靖12,凌浩威12,史凯旋12,刘 蓉12,肖朝江12,姜 北12*   

  1. 1.云南省滇西抗病原植物资源筛选研究重点实验室,云南大理  6710002.大理大学药学院,云南大理  671000

  • 收稿日期:2023-01-09 修回日期:2023-02-14 出版日期:2023-08-15 发布日期:2023-07-11
  • 通讯作者: 姜北,教授,博士,E-mail:jiangbei@dali.edu.cn。
  • 作者简介:李靖,硕士研究生,主要从事天然产物研究。
  • 基金资助:
    国家自然科学基金项目(81960637);云南省滇西抗病原植物资源筛选研究重点实验室项目(202105AG070003);云南省教育厅科学研究基金项目(2022Y822

Study on Chemical Constituents of the Root of Agapetes lacei var. tomentella

Li Jing12 Ling Haowei12 Shi Kaixuan12 Liu Rong12 Xiao Chaojiang12 Jiang Bei12*   

  1. 1. Yunnan Key Laboratory of Screening and Research on Anti-athogenic Plant Resources from Western Yunnan Dali Yunnan 671000 China 2. College of Pharmacy Dali University Dali Yunnan 671000 China

  • Received:2023-01-09 Revised:2023-02-14 Online:2023-08-15 Published:2023-07-11

摘要: 目的:研究绒毛灯笼花Agapetes lacei var. tomentella干燥块根中的化学成分。方法:采用硅胶柱色谱和薄层色谱法对绒毛灯笼花块根75%乙醇提取物乙酸乙酯部位进行分离纯化,依据理化性质及现代波谱技术对化合物进行结构鉴定。结果:从绒毛灯笼花块根75%乙醇提取物乙酸乙酯部位中分离得到10个化合物,分别鉴定为:3α,23-O-异亚丙基-2α,19α-二羟基-12--28-乌苏酸(1)、3β,23-O-异亚丙基-2α,3β,23-三羟基-12--28-齐墩果酸(2)、2α,3α,19α,23-四羟基-12--28-乌苏酸(3)、2α,3β,23-三羟基-12--28-齐墩果酸(4)、3β-乙酰乌苏酸(5)、乌苏酸(6)、β-谷甾醇(7)、5α,6β-二羟基谷甾醇(8)、胡萝卜苷(9)、4-羟基丁酸(10)。结论:所有化合物均为首次从绒毛灯笼花中分离得到,除化合物79外,其余化合物均为首次从树萝卜属植物中分离得到。

关键词: font-family:宋体, ">font-family:宋体, ">绒毛灯笼花, 树萝卜属, 化学成分, 三萜, 甾体

Abstract: Objective To study the chemical constituents of the dried root of Agapetes lacei var. tomentella. Methods Silica gel column chromatography and thin layer chromatography were used to isolate and purify the ethyl acetate fraction of the 75% ethanol extract of the root of A. lacei var. tomentella and the chemical structures of the compounds were identified based on physicochemical properties and modern spectroscopic techniques. Results Ten compounds were isolated from the ethyl acetate fraction of the 75% ethanol extract of the root of A. lacei var. tomentella and identified as 3α,23-O-isopropylidenyl-2α,19α-dihydroxyurs-12-en-28-oic acid1), 3β, 23-O-isopropylidenyl-2α,3β,23-trihydroxyolean-12-en-28-oic acid2), 2α,3α,19α,23-tetrahydroxyurs-12-en-28-oic acid3), 2α,3β,23-trihydroxyolean-12-en-28-oic acid4), 3β-acetoxy ursolic acid5), ursolic acid6), β-sitosterol7), 5α,6β-dihydroxysitosterol8), daucosterol9), and 4-hydroxybutanoic acid10. Conclusion All the compounds were isolated from A. lacei var. tomentella for the first time except for compounds 7 and 9 the other compounds were first isolated from genus Agapetes.

Key words: font-family:Times New Roman, ">Agapetes lacei var. tomentellafont-family:Times New Roman, ">, font-family:Times New Roman, "> Agapetesfont-family:Times New Roman, ">, font-family:Times New Roman, "> chemical constituentsfont-family:Times New Roman, ">, font-family:Times New Roman, "> triterpenoidsfont-family:Times New Roman, ">, font-family:Times New Roman, "> steroids

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