关键词: font-family:Times New Roman, ">铁死亡；font-family:Times New Roman, ">Web of Sciencefont-family:Times New Roman, ">；科学计量学

Abstract: Objective： To explore the hot topics and development trends of research related to ferroptosis in the Core collection of the Web of Science database in recent 10 years using scientometric analysis and provide reference for further research in this field. Methods： A search was conducted in the Core collection of the Web of Science database using the term "Ferroptosis" and the index date range of "2012-01-01" to "2021-12-31". The literature type was set to "article"， and the collected data were subjected to scientometric analysis. Results：A total of 2 254 literatures related to ferroptosis were retrieved， and the number of published papers showed an increasing trend year by year. The country with the largest number of published papers was China， and the institution with the largest number of published papers was Shanghai Jiao Tong University. The institutional temporal co-occurrence network showed that although Chinese institutions published more papers， their research started late. The main research directions of ferroptosis were biochemistry and molecular biology. The cluster with the most co-occurrence keywords was the treatment and prognosis of ferroptosis-related diseases. The cited outburst keywords showed that apoptosis and oxidative stress were the research hotspots in the first 5 years， while diseases and p53 were the research hotspots in the last 5 years. The top three ferroptosis-related diseases were breast cancer， lung cancer and liver cancer. Conclusion： Ferroptosis is currently a hot topic of research， and China is actively engaged in the research field of ferroptosis. With the passage of time， the research focus has gradually shifted from basic experiments on the mechanism of ferroptosis to clinical research on the treatment and prognosis of ferroptosis-related diseases.

Key words: font-family:Times New Roman, ">ferroptosisfont-family:Times New Roman, ">；font-family:Times New Roman, "> Web of Sciencefont-family:Times New Roman, ">；font-family:Times New Roman, "> scientometrics