大理大学学报 ›› 2023, Vol. 8 ›› Issue (10): 85-89.

• 临床医学 • 上一篇    下一篇

绝经后女性甲状腺功能亢进与骨密度的相关性分析

李 烨12,虞艳芳3,陈 斌3,苏 恒3*   

  1. 1.云南省第一人民医院药学部,昆明 6500322.昆明理工大学附属医院药学部,昆明 6500323.云南省第一人民医院内分泌代谢科,昆明 650032

  • 收稿日期:2022-05-31 修回日期:2022-09-14 出版日期:2023-10-15 发布日期:2023-10-26
  • 通讯作者: 苏恒,主任医师,博士,E-mail:su_hen@hotmail.com。
  • 作者简介:李烨,主管药师,博士研究生,主要从事甲状腺疾病与骨代谢研究。
  • 基金资助:

    云南省医学领军人才项目(L-201624);云南省万人计划名医专项(YNWR-MY-2019-020);云南省教育厅科学研究基金项目(2021J0009

Correlation Analysis of Hyperthyroidism and Bone Mineral Density in Postmenopausal Women

Li Ye12Yu Yanfang3Chen Bin3Su Heng3*   

  1. 1. Department of PharmacyThe First People's Hospital of Yunnan ProvinceKunming 650032China2. Department of PharmacyAffiliated Hospital of Kunming University of Science and TechnologyKunming 650032China3. Department of Endocrinology and MetabolismThe First People's Hospital of Yunnan ProvinceKunming 650032China

  • Received:2022-05-31 Revised:2022-09-14 Online:2023-10-15 Published:2023-10-26

摘要:

目的:探讨绝经后女性甲状腺功能亢进与各部位骨密度的相关性。方法:选取202110月至20224月在云南省第一人民医院就诊的220例绝经后女性作为研究对象,比较所有受试者的骨密度值和甲状腺功能指标水平,并按病程长短将甲状腺功能亢进症患者分成不同亚组,比较亚组间骨密度值测量情况。结果:甲状腺功能亢进症患者腰椎、股骨颈、Wards三角、大粗隆、全身的骨密度值显著低于非甲状腺功能亢进症者,病程≥1年的甲状腺功能亢进症患者腰椎骨密度值显著低于病程<1年者(P<0.05);游离三碘甲状腺原氨酸(FT3)水平与股骨颈、Wards三角和全身骨密度值呈负相关,游离甲状腺素(FT4)水平与Wards三角骨密度值呈负相关。结论:绝经后甲状腺功能亢进女性的骨密度值显著低于绝经后非甲状腺功能亢进女性,病程延长更容易导致腰椎骨密度值下降,FT3FT4水平与骨密度值呈负相关。

关键词:

骨密度, 甲状腺激素, 甲状腺功能亢进, 绝经后女性, 相关性

Abstract:

ObjectiveTo explore the correlation between hyperthyroidism and bone mineral densityBMDin postmenopausal women. MethodsA total of 220 postmenopausal women who visited the First People's Hospital of Yunnan Province from October 2021 to April 2022 were selected as the study subjects. BMD and thyroid function indicators were compared among all participants. The patients with hyperthyroidism were divided into different subgroups according to the duration of the diseaseand BMD measurements were compared among the subgroups. ResultsThe BMD values of lumbar vertebraneck of femurWards trianglegreater trochanter and the whole body in patients with hyperthyroidism were significantly lower than in those without hyperthyroidism. Among patients with hyperthyroidismthose with a disease duration of 1 year had significantly lower BMD values in the lumbar spine compared to those with a disease duration of <1 yearP<0.05. The levels of free triiodothyronineFT3were negatively correlated with BMD values in the neck of femurWards triangleand the whole bodywhile the levels of free thyroxineFT4were negatively correlated with BMD values in Wards triangle. ConclusionThe BMD values of postmenopausal women with hyperthy-roidism are significantly lower than those without hyperthyroidism. Prolonged disease duration is more likely to lead to a decrease in lumbar spine BMD. FT3 and FT4 levels are negatively correlated with BMD values.

Key words:

bone mineral density, thyroid hormone, hyperthyroidism, postmenopausal women, correlation

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