大理大学学报 ›› 2024, Vol. 9 ›› Issue (2): 4-7.

• 药学 • 上一篇    下一篇

扶正辟邪颗粒挥发油提取及包合工艺研究

罗 群,任桂林,蒲清荣,任 维,王饶琼,梁 盼,杨思进*   

  1. (西南医科大学附属中医医院,四川泸州 646000)
  • 收稿日期:2023-01-31 修回日期:2023-04-18 出版日期:2024-02-15 发布日期:2024-02-23
  • 通讯作者: 杨思进,主任中医师,E-mail:ysjimn@sina.com。
  • 作者简介:罗群,主管药师,主要从事中药制剂研究。
  • 基金资助:
    四川省中医药管理局项目(2021XYCZ006);西南医科大学-附属中医医院联合项目(2020XYLH-004)

Study on Extraction and Inclusion Processes of Volatile Oil from Fuzheng Pixie Granules

Luo Qun, Ren Guilin, Pu Qingrong, Ren Wei, Wang Raoqiong, Liang Pan, Yang Sijin*   

  1. (The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China)
  • Received:2023-01-31 Revised:2023-04-18 Online:2024-02-15 Published:2024-02-23

摘要: 目的:优化扶正辟邪颗粒挥发油提取及包合工艺。方法:采用L9(34)正交设计试验,以挥发油得油率为指标,优选挥发
油提取工艺;以包合物收率和挥发油包合率为指标,优选挥发油β-环糊精包合工艺。结果:最佳挥发油提取工艺为10倍量的
水,浸泡0.5 h,提取4.5 h,3次验证试验平均挥发油得油率为(0.91±0.01)%;最佳挥发油包合工艺为β-环糊精与挥发油比例为
10:1,包合温度40 ℃,包合3 h,3次验证试验平均包合物收率为(84.48±0.75)%,平均挥发油包合率为(90.69±0.79)%。结论:扶
正辟邪颗粒挥发油最佳提取工艺及最佳包合工艺设计合理、结果稳定,适宜于工业生产。

关键词: 扶正辟邪颗粒, 挥发油, β-环糊精, 提取工艺, 包合工艺

Abstract: Objective: To optimize the extraction and inclusion process of volatile oil from Fuzheng Pixie granules. Methods: L9(34)
orthogonal design experiment was used to optimize the extraction process of volatile oil, with the oil yield as the index. The inclusion
process of volatile oil with β-cyclodextrin was optimized with the yield of inclusion complex and the inclusion rate of volatile oil as the
indexes. Results: The optimal extraction process of volatile oil was soaking in 10 times the amount of water for 0.5 hours, followed by
extraction for 4.5 hours. The average oil yield of volatile oil in three verification tests was (0.91±0.01)%. The optimal inclusion process
of volatile oil was a ratio of β-cyclodextrin to volatile oil of 10:1, inclusion temperature of 40 ℃, and inclusion time of 3 hours. The
average yield of inclusion complex in three verification tests was (84.48±0.75)%, and the average inclusion rate of volatile oil was
(90.69±0.79)% . Conclusion: The optimal extraction process and the optimal inclusion process of volatile oil of Fuzheng Pixie
granules are reasonable in design and stable in results, which are suitable for industrial production.

Key words: Fuzheng Pixie granules, volatile oil, β-cyclodextrin, extraction process, inclusion process

中图分类号: