薄荷油对小鼠肝肾损伤的动物实验研究

J4 ›› 2012, Vol. 11 ›› Issue (12): 6-9.

薄荷油对小鼠肝肾损伤的动物实验研究

目的：从病理学形态改变的角度探索薄荷提取液对肝脏和肾脏的损伤作用。方法：实验以昆明小白鼠为研究对象，将其
随机分组，采用灌胃的方法给予不同剂量薄荷油。从病理学角度观察其肝、肾器官形态改变，以了解该植物提取液的毒性和致
死量。结果：通过急性实验，发现大剂量薄荷油对小白鼠的肝、肾均有损伤作用，随着剂量的增加，病理变化随之明显。组织切片
显示肝细胞水肿和脂肪变性，肾小管上皮也可见一定的损伤，表现为上皮细胞水肿。结论：大剂量薄荷油对小鼠的肝、肾均有损
伤作用，肝毒性显著，并对肾脏有轻度毒性。

1.大理学院临床医学院，云南大理 671000；2.大理学院基础医学院，云南大理 671000

收稿日期:2012-05-29 修回日期:2012-09-20 出版日期:2012-12-15 发布日期:2012-12-15
作者简介:李枝，2009级临床医学专业本科生.
基金资助:
大理学院大学生科研基金资助项目（KYSX2011008）

Liver and Kidney Damage Induced by Peppermint Oil on Mice Model

Objective: To investigate the injury effect of peppermint extract on mice liver and kidney using pathological method.
Methods: Kunming mice subjected peppermint oil by intragastrical way were randomized in to different peppermint oil doses groups.
Pathological alternations were observed and the amounts of lethal and toxicity of plant extracts were examined. Results: With acute
experiments, we found that large doses of peppermint oil could induce mouse liver and kidney damage, and with the dose increased,
pathological changes were severe.Tissue slices showed edema and fatty degeneration on liver cells, and edema on the kidney
epithelial cells. Conclusion: Large doses of peppermint oil were damage to both mouse liver and kidney,but in different extents.

1.Clinical College, Dali University, Dali, Yunnan 671000, China; 2. Pre-clinical College,
Dali University, Dali, Yunnan 671000, China

Received:2012-05-29 Revised:2012-09-20 Online:2012-12-15 Published:2012-12-15

摘要/Abstract

摘要：

关键词: 薄荷油, 小白鼠, 肝毒性, 肾毒性, 量效关系

Abstract:

Key words: peppermint oil mice, liver toxicity, kidney toxicity, dose-effect relationship

中图分类号:

R361

李枝, 李进, 李世开, 和海燕, 师涛, 张庆, 陈海滨. 薄荷油对小鼠肝肾损伤的动物实验研究[J]. J4, 2012, 11(12): 6-9.

LI Zhi, LI Jin, LI Shi-Kai, HE Hai-Yan- , SHI Tao, ZHANG Qing, CHEN Hai-Bin. Liver and Kidney Damage Induced by Peppermint Oil on Mice Model[J]. J4, 2012, 11(12): 6-9.