PPARα在器官移植中的作用初探

J4 ›› 2012, Vol. 11 ›› Issue (12): 10-12.

PPARα在器官移植中的作用初探

目的：探讨PPARα在器官移植中的作用。方法：C57BL/6J经口给予非诺贝特或者Wy14643，连续7 d，取脾脏，同时取
BALB/c小鼠的脾脏，分离脾细胞进行混合淋巴细胞反应。结果：经过非诺贝特或者Wy14643处理的小鼠，其脾细胞在混合淋巴细
胞反应中表现为无应答。结论：非诺贝特或者Wy14643激活的PPARα具有抑制混合淋巴细胞反应的作用。

大理学院临床医学院，云南大理 671000

收稿日期:2012-09-20 修回日期:2012-10-24 出版日期:2012-12-15 发布日期:2012-12-15
作者简介:张元元，高级讲师，主要从事临床医学教学及研究.

Effects of PPARα on Organ Transplantation

Objective: To investigate the effect of PPARα on organ transplantation on mice model. Methods: Fenofibrate, Wy14643,
or vehicle was given through a feeding needle once per day for 7 consecutive days on C57BL/6J, spleen from C57BL/6J or BALB/c
was collected and splenocyte was isolated. Mixed lymphocyte reaction （MLR）was carried out. Results: The splenocyte was no
response in MLR from the mice treated with fenofibrate, or Wy14643. Conclusion: PPARα could be activated by fenofibrate, or
Wy14643, could inhibit MLR.

Clinical College, Dali University, Dali, Yunnan 671000, China

Received:2012-09-20 Revised:2012-10-24 Online:2012-12-15 Published:2012-12-15

摘要/Abstract

摘要：

关键词: 器官移植, PPARα, 非诺贝特, Wy14643

Abstract:

Key words: organ transplantation, PPARα, fenofibrate, Wy14643

中图分类号:

S857.13
R617

张元元, 李耀康, 王敏, 尹红春, 王光明. PPARα在器官移植中的作用初探[J]. J4, 2012, 11(12): 10-12.

ZHANG Yuan-Yuan, LI Yao-Kang, WANG Min, YIN Hong-Chun, WANG Guang-Ming. Effects of PPARα on Organ Transplantation[J]. J4, 2012, 11(12): 10-12.

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