关键词: 洛铂, 重组人血管内皮抑素, 肺癌, 恶性胸腔积液

Abstract:

Objective: To study the efficacy and safety of intrapleural injection of lobaplatin combined with endostar in treatment of
lung cancer with malignant pleural effusion. Methods: Sixty-three patients diagnosed lung cancer with malignant pleural effusion
were treated by the way of intrapleural injection. The subjects were divided into two groups: 32 cases were injected lobaplatin and
endostar (A group), 31 cases were injected cisplatin and endostar (B group). The clinical efficacy, quality of life and toxic reaction
were compared between groups. Results: The clinical efficacy and quality of life were not significantly different between two groups
(P>0.05). The incidences of WBC reduction, hypohemia, sicchasia and vomit were significant higher in B group than that in A (P<0.05). Conclusion: Lobaplatin combined with endostar therapy showed almost the same clincal efficacy compared to the therapy of
cisplatin combined with endostar in treatment of lung cancer with malignant pleural effusion, but with less side effect.

Key words: lobaplatin, endostar, lung cancer, malignant pleural effusion