J4 ›› 2014, Vol. 13 ›› Issue (2): 15-19.

• 药学 • 上一篇    下一篇

聚类分析法对不同产地半夏药材质量的综合评价

  

  1. 大理学院药学与化学学院,云南大理 671000
  • 收稿日期:2013-11-08 修回日期:2013-12-10 出版日期:2014-02-15 发布日期:2014-02-15
  • 作者简介:甫志锦,药学专业2010级本科生.
  • 基金资助:

    大理学院教学改革重点资助项目(JG200506)

Comprehensive Quality Evaluation of Rhizoma Pinelliae from Different Origin by Clustering Analysis
Method

  1. College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000,China
  • Received:2013-11-08 Revised:2013-12-10 Online:2014-02-15 Published:2014-02-15

摘要:

目的:综合比较、评价不同产地半夏药材的质量。方法:采用电位滴定法、紫外分光光度法、硫酸-蒽酮法和酸性染料比
色法对不同产地半夏药材中的总有机酸、氨基酸、多糖和生物碱含量进行测定,并采用聚类分析法对测定结果进行综合评价。结果:不同产地的半夏药材中总有机酸、氨基酸、多糖和生物碱的含量差异较大。结论:半夏药材的质量受产地影响较大,经聚类分析可将39份来源不同的半夏药材分为Ⅲ类,第Ⅰ类产地主要为云南、贵州地区,这类药材中总有机酸、氨基酸、多糖和生物碱的含量普遍偏低,综合质量较差;第Ⅱ类产地为甘肃,质量居中;第Ⅲ类产地为四川,这类药材中各主要成分的含量较高,综合质量较好。

关键词: 半夏药材, 不同产地, 聚类分析

Abstract:

Objective: To comprehensively compare and evaluate the quality of Pinellia ternate from different origin. Methods:
Electrometric titration, UV spectrophotometry and sulfuric acid-anthrone method were applied to determine the organic acids, amino acids and polysaccharides. The results of the above were conducted cluster analysis for comprehensive evaluation. Results: The content of total organic acid, polysaccharide and amino acids differed greatly in Pinellias ternate from different origins. Apart from No. 3, No. 25, No. 29 and No. 34 samples of Yunnan origin, the remaining samples passed the requirements of medicinal. Conclusion: The quality of Pinellia ternata was greatly influenced by the place of production. The cluster analysis could divide 39 different Pinellia ternata into 3 categories. Type I were most from Yunnan and Guizhou areas, which showed lower total content of organic acids, amino acids and
polysaccharides, as well as poorer comprehensive quality. Type III were from Sichuan area, which showed higher content of total organic acid better comprehensive quality.

Key words: Pinellia ternate, different origin, cluster analysis

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