云南松松塔不同极性部位对不同状态豚鼠离体气管的影响

doi:1672-2345.2015.08.001

J4 ›› 2015, Vol. 14 ›› Issue (8): 1-4.DOI: 1672-2345.2015.08.001

• 药学 • 下一篇

云南松松塔不同极性部位对不同状态豚鼠离体气管的影响

（1.武汉大学基础医学院，武汉430072；2.云南省昆虫生物医药研发重点实验室，云南大理671000；
3.保山中医药高等专科学校，云南保山678000）

收稿日期:2015-04-10 出版日期:2015-08-15 发布日期:2015-08-15
作者简介:郭美仙，实验师，主要从事中药药理学研究.
基金资助:
国家自然科学基金资助项目（81260632）；云南省自然科学基金资助项目（2012FD036）

The Influence of Different Polar Parts of Pinus yunnanensis on Trachea in Vitro of Guinea Pigs in Different State

（1. College of Basic Medicine, Wuhan University, Wuhan 430072, China; 2. Yunnan Provincial Key Laboratory of Entomological
Biopharmaceutical, Dali University, Dali, Yunnan 671000, China; 3. Baoshan College of Traditional Chinese Medicine, Baoshan,
Yunnan 678000, China）

Received:2015-04-10 Online:2015-08-15 Published:2015-08-15

摘要/Abstract

摘要：

目的：观察云南松松塔不同极性部位对不同状态豚鼠离体气管的解痉作用。方法：采用离体气管法，观察云南松松塔
不同极性部位对静息、乙酰胆碱（Ach）和组胺（His）致痉豚鼠离体气管的影响。结果：云南松松塔乙醇浸膏、石油醚部位和氯仿
部位可以降低静息离体气管的张力，明显提高基础解痉率；云南松松塔乙醇浸膏、石油醚部位、氯仿部位和乙酸乙酯部位可以
降低Ach、His致痉的离体气管张力，明显提高致痉气管的解痉率。结论：云南松松塔乙醇浸膏、石油醚部位和氯仿部位可提高
不同状态豚鼠离体气管的解痉率，对静息和致痉离体气管平滑肌有松弛作用。

关键词: 云南松松塔, 离体气管, 解痉作用

Abstract:

Objective: To observe the spasmolytic action of different polar parts of Pinus yunnanensis on trachea in vitro of guinea
pigs in different state. Methods: Using the methods of trachea in vitro, the influence of different polar parts of P. yunnanensis on
trachea in vitro in resting state and acetylcholine（Ach）or histamine（His）induced spasm state were observed. Results: Ethanol
extract, petroleum ether and chloroform parts of P. yunnanensis can reduce the tension of trachea in vitro in resting state and
significantly increase basic spasmolysis rate; Ethanol extract, petroleum ether, chloroform and ethyl acetate parts of P. yunnanensis can
reduce the tension of trachea in vitro in the Ach, His induced spasm state and significantly increase spasmolysis rate of spasmodic
trachea. Conclusion: Ethanol extract, petroleum ether and chloroform part of P. yunnanensis can improve the spasmolysis rate of
trachea in vitro of guinea pigs in different state, and relax resting and spasmodic trachea.

Key words: Pinus yunnanensis, trachea in vitro, spasmolytic effect

中图分类号:

R996.2

郭美仙，刘光明，沈磊，李冬梅，赵健荣，杨静. 云南松松塔不同极性部位对不同状态豚鼠离体气管的影响[J]. J4, 2015, 14(8): 1-4.

Guo Meixian, Liu Guangming, Shen Lei, Li Dongmei, Zhao Jianrong, Yang Ji. The Influence of Different Polar Parts of Pinus yunnanensis on Trachea in Vitro of Guinea Pigs in Different State[J]. J4, 2015, 14(8): 1-4.

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云南松松塔不同极性部位对不同状态豚鼠离体气管的影响

The Influence of Different Polar Parts of Pinus yunnanensis on Trachea in Vitro of Guinea Pigs in Different State

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