Research on the

doi:10. 3969 / j. issn. 2096-2266. 2026. 02. 002

Abstract

Abstract: Objective: To explore the synthesis of a series of compounds with isoprene side chains using brominated aromatic hydro⁃
carbons as starting materials. Methods: At 135 ℃, the palladium-catalyzed Heck-dehydration reaction was adopted to introduce the
isoprene side chain through the "one-pot" protocol. Results: Twelve compounds containing isoprene side chains were successfully syn⁃
thesized using the "one-pot" protocol. Conclusion: A synthetic strategy with a short route and high atomic economy has been devel⁃
oped, which solves the problems of complex steps and high cost in traditional methods and enables the simple construction of complex
molecules.

Key words: isoprene, one-pot, Heck-dehydration, palladium metal catalysis

CLC Number:

R284

Zhang Haipeng, Wang Lihua, Lei Ting, Jiang Shizhi, . Research on the "One-Pot" Synthesis of Isoprene Compounds[J]. Journal of Dali University, 2026, 11(2): 7-14.

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Research on the "One-Pot" Synthesis of Isoprene Compounds

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