Investigation of Two Novel Extraction Methods Coupled with Spectrophotometry for the Detection of
Lomefloxacin Hydrochloride

Abstract

Abstract:

Objective: Surfactant-assisted dispersive liquid-liquid microextraction（SA-DLLME）and ultrasound-assisted dispersive
liquid-liquid microextraction（UA-DLLME）were coupled with conventional spectrophotometer to pre-concentrate and determine
lomefloxacin hydrochloride（LMFH）, as well as to compare their analytical performances. Methods: The experimental conditions were
optimized and the analytical performances of the two kinds of DLLME techniques for LMFH determination were compared. Results:
After optimization, the LODs were 4.0 μg/L and 6.0 μg/L for SA-DLLME and UA-DLLME, respectively, with the enhancement factors
of 31 and 20 folds. Conclusion: The analytical performance of SA-DLLME was obviously better than UA-DLLME. The developed
methods were applied to the determination of LMFH in real samples with satisfactory analytical results.

Key words: surfactant-assisted dispersive liquid-liquid microextraction, ultrasound-assisted dispersive liquid-liquid microextraction, pre-concentration, spectrophotometer, lomefloxacin hydrochloride

CLC Number:

R917

Lei Zirong, Yang Shu, Yang Shengchun, Wen Xiaodong. Investigation of Two Novel Extraction Methods Coupled with Spectrophotometry for the Detection of
Lomefloxacin Hydrochloride[J]. , 2016, 1(12): 30-35.

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