Study on the Mechanism of Antihypertensive Effect of Plantain Seed Based on Network Pharmacology

Abstract

Abstract:

Objective: To analyze the mechanism of antihypertensive effect of Plantain seed by using the method of network
pharmacology. Methods: The chemical components and targets related to Plantain seed were searched from the TCMSP Database and
Analysis Platform. Hypertension-related targets were screened by DisGeNET database. The compound-target network was established
by Cytoscape 3.2.1 software and the PPI network were established by STRING Database. The GO enrichment analysis and KEGG
pathway analysis of the targets were performed with DAVID database. Results: 6 effective components were obtained from Plantain
seed, corresponding to 157 targets, and a total of 90 targets of hypertension were selected. The PPI network contained 65 proteins,
including IL6, AKT1, etc. The GO functional enrichment analysis showed 34 GO entries. The KEGG pathway enrichment analysis
showed 36 pathways, involving PI3K-Akt signaling pathway, HIF-1 signaling pathway, and TNF signaling pathway, etc. Conclusion:
The result of this study preliminarily verifies the basic pharmacological antihypertensive mechanism of Plantain seed, which also lays a
good foundation for further studies.

Key words: network pharmacology, Plantain seed, antihypertensive, functionary mechanism

CLC Number:

R285.5

XU Ya, DIAO Qi. Study on the Mechanism of Antihypertensive Effect of Plantain Seed Based on Network Pharmacology[J]. , 2019, 4(8): 33-38.

References

〔1〕国家药典委员会. 中华人民共和国药典：一部〔M〕. 北
京：中国医药科技出版社，2015：68-69.
〔2〕斯日棍其其格，董成海. 车前子的化学成分及药理学研
究〔J〕. 世界最新医学信息文摘，2017，17（94）：97-98.
〔3〕刘维忠. 单味车前子可降血压〔N〕. 中国中医药报，
2017-06-12（5）.
〔4〕李杨，郝俊杰. 基于网络药理学的当归补血汤治疗贫血
的作用机制研究〔J〕. 大理大学学报，2018，3（10）：1-6.
〔5〕黎梓旺，温庆华，许媛. 化痰熄风活血散瘀方治疗高血压
病临床观察〔J〕. 光明中医，2019（4）：584-587.
〔6〕贺建涛. 熄风通络汤合并针刺治疗原发性高血压的临床
观察〔J〕. 中国民间疗法，2019，27（2）：56-58.
〔7〕李冲冲，龚苏晓，许浚，等. 车前子化学成分与药理作用
研究进展及质量标志物预测分析〔J〕. 中草药，2018，49
（6）：1233-1246.
〔8〕王辉，何柏球，王立英，等. 高车前苷改善棕榈酸所致的
血管内皮细胞凋亡〔J〕. 中药药理与临床，2014，30（3）：
39-42.
〔9〕GUO X D，ZHANG D Y，GAO X J，et al. Quercetin and quercetin-3-O-glucuronide are equally effective in amelio?
rating endothelial insulin resistance through inhibition of
reactive oxygen species-associated inflammation〔J〕. Mol
Nutr Food Res，2013，57（6）：1037-1045.
〔10〕GENG F，YANG L，CHOU G，et al. Bioguided isolation of
angiotensin-converting enzyme inhibitors from the seeds
of Plantago asiatica L.〔J〕. Phytother Res，2010，24（7）：
1088-1094.
〔11〕林化，黄文新，谭宁. NADPH氧化酶在高血压炎症进程
中的意义〔J〕. 医学综述，2009，15（5）：648-650.
〔12〕朱健，陈谊，王曹峰，等. 细胞因子与高血压病患者左室
构型的相关性研究〔J〕. 中华老年心脑血管病杂志，
2005（3）：166-168.
〔13〕GUPTA N，DUGGAL S，KUMAR A，et al. Concurrent in?
teractome and metabolome analysis reveals role of AKT1
in central carbonmetabolism〔J〕. BMC Res Notes，2018，
11（1）：270.
〔14〕翟哲民. 高血压前期病变与糖脂代谢异常的相关性分
析〔J〕. 中国实验诊断学，2019，23（1）：43-46.
〔15〕杨宁. 普罗布考、厄贝沙坦对胰岛素PI3K/Akt信号转导
通路及高血压相关因素影响的实验研究〔D〕. 天津：天
津医科大学，2009.
〔16〕张爱民，蒋宗滨. 高压氧预处理通过HIF-1α/VEGF通
路减轻大脑缺血再灌注损伤〔J〕. 中国病理生理杂志，
2018，34（11）：2048-2053.
〔17〕王景胜，刘正君，陈楠. hsCRP、TNF-α与高血压性脑出
血相关性研究进展〔J〕. 心血管康复医学杂志，2018，27
（5）：613-615.
〔18〕徐锋，陈滕，汪祖华，等. 基于网络药理学的黄精抗糖尿
病作用机制研究〔J〕. 大理大学学报，2019，4（2）：21-26.

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