›› 2019, Vol. 4 ›› Issue (8): 39-42.

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Apatinib Combined with Radiochemotherapy for Advanced Colorectal Cancer in 2 Cases and
Literature Review

Zhang Jianyi1, Zhang Jing2, Wang Jianhua2, Duan Saizhu2, Zhang Rongsheng2*   

  1. (1. Clinical College, Dali University, Dali, Yunnan 671000, China; 2. The First Affiliated Hospital of Dali University,
    Dali, Yunnan 671000, China)
  • Received:2018-09-28 Revised:2019-04-10 Online:2019-08-15 Published:2019-08-15

Abstract:

Objective: To retrospectively analyze the efficacy and safety of apatinib combined with radiochemotherapy in the
treatment of advanced colorectal cancer. Methods: The efficacy and safety of two patients with advanced colorectal cancer treated with
apatinib combined with radiochemotherapy were analyzed and related literatures were reviewed. Results: Two patients were followed
up for 12 months, all of whom had achieved stable disease and benefited from overall survival. The main adverse reactions were fatigue,
oral pain, and were tolerable after treatment or dose adjustment. Conclusion: The efficacy of apatinib combined with radiochemotherapy
in the treatment of advanced colorectal cancer is positive, and adverse reactions can be tolerated.

Key words: advanced colorectal cancer, apatinib, combination therapy, curative effect analysis

CLC Number: