Effects of Serum HGF, uPA, IL-17, and IL-24 on the Prognosis of Patients with Oral Squamous#br#
Cell Carcinoma

doi:10. 3969 / j. issn. 2096-2266. 2025. 02. 013

Abstract

Abstract: Objective: To investigate the impact of serum hepatocyte growth factor （HGF）, urokinase plasminogen activator （uPA）,
interleukin-17 （IL-17）, and interleukin-24 （IL-24） on the prognosis of patients with oral squamous cell carcinoma （OSCC）.
Methods: A retrospective analysis was conducted on clinical data from 75 OSCC patients. Preoperative serum levels of HGF, uPA, IL-
17, and IL-24 were measured, and the differences in these biomarkers among patients with varying clinical characteristics were
compared. Kaplan-Meier survival analysis and COX regression models were used to assess the impact of these biomarkers on
prognosis. Receiver operator characteristic curves were employed to evaluate the diagnostic efficacy of each biomarker. Results:
Kaplan-Meier analysis and COX regression results indicated that the degree of differentiation, clinical stage, and the levels of the
aforementioned serum biomarkers were independent factors influencing OSCC prognosis. The area under the curve values for each
biomarker′s prognostic prediction were relatively high. Conclusion: Serum levels of HGF, uPA, IL-17, and IL-24 are closely related
to the prognosis of OSCC patients and can serve as important prognostic indicators. Integrating these biomarkers with clinical
characteristics helps in predicting prognosis and guiding personalized treatment.

Key words: oral squamous cell carcinoma, prognosis, diagnosis

CLC Number:

R739.8

Hong Xiao¹, Liao Shengkai¹, Zhou Jing², Li Jiancheng¹. Effects of Serum HGF, uPA, IL-17, and IL-24 on the Prognosis of Patients with Oral Squamous#br# Cell Carcinoma[J]. Journal of Dali University, 2025, 10(2): 60-66.

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Effects of Serum HGF, uPA, IL-17, and IL-24 on the Prognosis of Patients with Oral Squamous#br# Cell Carcinoma

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