Study on the Diagnostic Value of Serum Markers in the Natural History of Chronic HBV Infection

doi:10. 3969 / j. issn. 2096-2266. 2025. 02. 014

Abstract

Abstract: Objective: To evaluate the diagnostic value of serum markers in the staging of chronic HBV infection throughout its
natural history. Methods: A retrospective analysis was conducted on the clinical data of 172 patients with chronic HBV infection, who
had not undergone antiviral treatment, collected from November 2020 to December 2023 at Kunming Third People′s Hospital . Based
on the natural history of chronic HBV infection, patients were classified into four groups: EPI, EPH, ENI, and ENH. Changes in serum
marker levels were compared among these groups, and the diagnostic value of each marker for the EPH and ENH stages was assessed
using ROC curve analysis. Results: Significant differences were observed among groups in age, RDW-SD, HBeAg, HBsAg, HBV
DNA, HBV RNA, ALT, AST, GGT, PT, PTA, APRI, FIB-4, and GPR levels （P<0.05）. Univariate analysis for HBeAg-positive and
HBeAg-negative patients revealed significant differences between the EPI and EPH groups in age, Hb, HBeAg, HBsAg, ALT, AST,
GGT, AFP, APRI, FIB-4, and GPR levels（ P<0.05）. Similarly, significant differences were found between the ENI and ENH groups in
HBV DNA, HBV RNA, ALT, AST, GGT, APRI, and GPR levels（ P<0.05）. ROC curve analysis indicated that the combined diagnostic
prediction using multiple serum markers had a higher diagnostic efficiency for the EPH and ENH stages compared to individual
markers. Conclusion: The combined diagnosis of multiple serum markers has high clinical value and is expected to provide
noninvasive diagnostic support for the staging of chronic HBV infection and the selection of antiviral therapy.

Key words: serum markers, hepatitis B virus, infection, natural history, diagnostic value

CLC Number:

R512.6

Yu Wenjun, Yu Tingting, Li Lihua, Wang Hongying, Pu Dong. Study on the Diagnostic Value of Serum Markers in the Natural History of Chronic HBV Infection[J]. Journal of Dali University, 2025, 10(2): 67-74.

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