Study on β-Hematin Formation Inhibition Activity of Radix Campylotropidis Hirtellae

Abstract

Abstract:

Objective: To study β-hematin formation inhibition activity of Radix Campylotropidis Hirtellae for finding new effective
antimalarial medicines. Methods: The crude extract, fractions and compounds from the plant were screened for antimalarial activities
by β-hematin formation inhibition assay, and the results were expressed as inhibition rate and IC50 values. The compounds were
obtained by column chromatography, and their structures were elucidated on the basis of spectral data. Results: The crude extract and
solvent fractions showed significant β- hematin formation inhibition activities, while only the compound 1 showed weak activity.
Conclusion: The crude extract and solvent fractions showed significant β-hematin formation inhibition activities. However, the active
constituents from this plant needs a deeper research as well.

Key words: Radix Campylotropidis Hirtellae, antimalarial activity, β-hematin formation inhibition assay, chemical constituents

CLC Number:

R978.61

Chen Hao, Liu Xiaowei, Shen Yi, Cui Shujun, Xiao Chaojiang. Study on β-Hematin Formation Inhibition Activity of Radix Campylotropidis Hirtellae[J]. , 2018, 3(2): 6-9.

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